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Dataset for Figure 1 - Leveling trend of published microRNA biomarker studies in common biofluids.

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: August 02, 2025 | Last Modified: 2020-04-15
PubMed was searched for the terms microRNA and biomarker in addition to blood (blue), urine (orange), saliva (grey), or cerebrospinal fluid (yellow). The graph in the paper displays the number of total annual publications over the past 16 years and the actual numbers used generate this graph are in incuded in the attached spreadsheet. A near annual doubling of publications occurred from the years 2009 until 2015, whereas only a mere 4% increase in annual publications from 2015 until 2018 was noted. While a number of factors can contribute to these publication trends, this indicates an overall cooling of research interest in biofluid-based microRNA biomarker development. This dataset is associated with the following publication: Chorley, B., E. Atabakhsh, G. Doran, J. Gautier, H. Ellinger-Ziegelbauer, D. Jackson, T. Sharapova, P. Yuen, R. Church, P. Couttet, R. Froetschl, J. McDuffie, V. Martine, P. Pande, L. Peel, C. Rafferty, F. Simutis, and A. Harrill. Methodological considerations for measuring biofluid-based microRNA biomarkers. CRITICAL REVIEWS IN TOXICOLOGY. Taylor & Francis Group, London, UK, 51(3): 264-282, (2021).

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