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Debate: Are surrogate end-point studies worth the effort?
Surrogate end-points of cardiovascular disease can provide useful information in cross-sectional, prospective and interventional studies. They provide information on association with risk factors, natural history and factors associated with disease progression. Because every participant can reach an end-point, sufficient power can be attained with much smaller numbers of subjects in surrogate end-point studies than in studies that use clinical endpoints, so that the costs are likely to be substantially less. Measures of carotid intima-media thickness (IMT) by B-mode ultrasonography and of coronary calcification by electron beam computed tomography (EBCT) appear to be the most promising surrogate end-points.
Complete Metadata
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| description | Surrogate end-points of cardiovascular disease can provide useful information in cross-sectional, prospective and interventional studies. They provide information on association with risk factors, natural history and factors associated with disease progression. Because every participant can reach an end-point, sufficient power can be attained with much smaller numbers of subjects in surrogate end-point studies than in studies that use clinical endpoints, so that the costs are likely to be substantially less. Measures of carotid intima-media thickness (IMT) by B-mode ultrasonography and of coronary calcification by electron beam computed tomography (EBCT) appear to be the most promising surrogate end-points. |
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|
| identifier | https://healthdata.gov/api/views/fjhu-hhjb |
| issued | 2025-07-14 |
| keyword |
[
"cardiovascular-disease",
"coronary-calcification",
"intima-media-thickness",
"nih",
"surrogate-endpoints"
]
|
| landingPage | https://healthdata.gov/d/fjhu-hhjb |
| modified | 2025-09-06 |
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| publisher |
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|
| theme |
[
"NIH"
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|
| title | Debate: Are surrogate end-point studies worth the effort? |
