Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays
This manuscript tests the hypothesis of dose additivity of an environmental mixture of pyrethriod insecticides at the level of network function, in vitro. The results demonstrate that permethrin, deltamethrin, esfenvalerate, cypermethrin and beta-cyfluthrin all change the activity of networks as measured by microelectrode arrays, and that the effects of an environmental-relevant mixture of these 5 compounds can be predicted based on a dose-additivity model.
These results are consistent with results from in vivo experiments that examined motor activity. This study supports the Office of Pesticides decision to regulate mixtures of pyrethroids based on dose additivity.
This dataset is associated with the following publication:
Johnstone , A., J. Strickland, K. Crofton , C. Gennings, and T. Shafer. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 60(16): 234-239, (2017).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Timothy Shafer",
"hasEmail": "mailto:shafer.tim@epa.gov"
}
|
| description | This manuscript tests the hypothesis of dose additivity of an environmental mixture of pyrethriod insecticides at the level of network function, in vitro. The results demonstrate that permethrin, deltamethrin, esfenvalerate, cypermethrin and beta-cyfluthrin all change the activity of networks as measured by microelectrode arrays, and that the effects of an environmental-relevant mixture of these 5 compounds can be predicted based on a dose-additivity model. These results are consistent with results from in vivo experiments that examined motor activity. This study supports the Office of Pesticides decision to regulate mixtures of pyrethroids based on dose additivity. This dataset is associated with the following publication: Johnstone , A., J. Strickland, K. Crofton , C. Gennings, and T. Shafer. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 60(16): 234-239, (2017). |
| distribution |
[
{
"title": "ShaferTimothy_SciHub Dataset for pyrethroid mixture.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1390091/ShaferTimothy_SciHub%20Dataset%20for%20pyrethroid%20mixture.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1390091 |
| keyword |
[
"Dose-additivity",
"Microelectrode array",
"Mixtures",
"in vitro",
"neurotoxicity",
"pyrethroids"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2015-09-09 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.neuro.2016.05.005"
]
|
| rights |
null
|
| title | Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays |
