Effects of Oleic Acid on Human Endothelal Cells
Figure 1. Comparison of cell viability in response to exposure of cells to oleic acid (in ethanol), a hydroxy-metabolite, or methylated oleic acid as percent of the vehicle control response.
Figure 2. Mitochondrial stress test extracellular flux using comparison of cellular oxygen consumption rate measures.
Figure 3. Soluble mediator release comparison of cells exposed to oleic acid and its metabolites.
Figure 4. Cellular iron-uptake following incubation with fatty acids.
Supplement 2A. Lactate dehydrogenase activity release ( a measure of cell viability) is dose- and time-dependent.
Supplement 2B. Oleic acid cellular association differs with vehicle utilized.
This dataset is associated with the following publication:
Bass, V., J. Soukup, A. Ghio, and M. Madden. Oleic Acid and Derivatives Affect Human Endothelial Mitochondrial Function Cell and Vasoactive Mediator Production. Lipids in Health and Disease. BioMed Central Ltd, London, UK, 19(1): 128, (2020).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
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| contactPoint |
{
"fn": "Michael Madden",
"hasEmail": "mailto:madden.michael@epa.gov"
}
|
| description | Figure 1. Comparison of cell viability in response to exposure of cells to oleic acid (in ethanol), a hydroxy-metabolite, or methylated oleic acid as percent of the vehicle control response. Figure 2. Mitochondrial stress test extracellular flux using comparison of cellular oxygen consumption rate measures. Figure 3. Soluble mediator release comparison of cells exposed to oleic acid and its metabolites. Figure 4. Cellular iron-uptake following incubation with fatty acids. Supplement 2A. Lactate dehydrogenase activity release ( a measure of cell viability) is dose- and time-dependent. Supplement 2B. Oleic acid cellular association differs with vehicle utilized. This dataset is associated with the following publication: Bass, V., J. Soukup, A. Ghio, and M. Madden. Oleic Acid and Derivatives Affect Human Endothelial Mitochondrial Function Cell and Vasoactive Mediator Production. Lipids in Health and Disease. BioMed Central Ltd, London, UK, 19(1): 128, (2020). |
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|
| identifier | https://doi.org/10.23719/1503700 |
| keyword |
[
"air pollutant",
"oleic acid",
"vascular toxicity"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2019-04-09 |
| programCode |
[
"020:094"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
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|
| references |
[
"https://doi.org/10.1186/s12944-020-01296-6"
]
|
| rights |
null
|
| title | Effects of Oleic Acid on Human Endothelal Cells |
