Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
Background:
Increased serum levels of procalcitonin (ProCT) and its component
peptides have been reported in humans with sepsis. Using a hamster model of
bacterial peritonitis, we investigated whether serum ProCT levels are elevated
and correlate with mortality and hypocalcemia.
Results:
Incremental increases in doses of bacteria resulted in
proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as
increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250,
380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml).
Gel filtration studies revealed that ProCT was the predominant (> 90%)
molecular form of serum iCT secreted. In the metabolic experiments, total iCT
peaked at 12 h concurrent with the maximal decrease in serum calcium.
Conclusions:
In this animal model, hyper-procalcitoninemia was an early
systemic marker of sepsis which correlated closely with mortality and had an
inverse correlation with serum calcium levels.
Complete Metadata
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| accessLevel | public |
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[
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|
| description | Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. Results: Incremental increases in doses of bacteria resulted in proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (> 90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. Conclusions: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels. |
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| identifier | https://healthdata.gov/api/views/v4da-zt5y |
| issued | 2025-07-13 |
| keyword |
[
"bacterial-peritonitis",
"hamster-model",
"nih",
"procalcitonin-levels",
"sepsis-mortality"
]
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| modified | 2025-09-06 |
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| theme |
[
"NIH"
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|
| title | Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis |
