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Expanded ORD PFAS SEM

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: August 02, 2025 | Last Modified: 2023-04-18

We used systematic evidence map methods to summarize the available epidemiological and animal bioassay evidence for an expanded set of ~345 PFAS that were prioritized in 2019 by the EPA’s Center for Computational Toxicology and Exposure (CCTE) for in vitro toxicity and toxicokinetic screening. This work builds upon our previously published evidence map for ~150 PFAS chemicals (Carlson et al. 2022, https://doi.org/10.1289/EHP10343). This dataset is associated with the following publication: Shirke, A., E. Radke-Farabaugh, C. Lin, R. Blain, N. Vetter, c. lemeris, p. hartman, H. Hubbard, M. Angrish, X. Arzuaga Andino, J. Congleton, J. Davis, L. Dishaw, R. Jones, R. Judson, J. Kaiser, A. Kraft, L. Lizarraga, P. Noyes, G. Patlewicz, M. Taylor, A. Williams, K. Chialton, and L. Carlson. Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 132(2): CID: 026001, (2024).

Resources

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https://hawc.epa.gov/assessment/100500256/

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https://heronet.epa.gov/heronet/index.cfm/project/page/project_id/2875

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https://heronet.epa.gov/heronet/index.cfm/project/page/project_id/2877

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https://public.tableau.com/app/profile/literature.inventory/viz/ComprehensivePFASEvidenceMapVisualizations/AnimalStudies

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https://public.tableau.com/app/profile/literature.inventory/viz/ExpandedPFASEvidenceMapVisualizations/ReadMe

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Expanded PFAS SEM_Supplemental Excel File.xlsx

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Expanded PFAS SEM_Supplemental Material.docx

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Complete Metadata

accessLevel	public
bureauCode	[ "020:00" ]
contactPoint	{ "fn": "Laura Carlson", "hasEmail": "mailto:carlson.laura@epa.gov" }
description	We used systematic evidence map methods to summarize the available epidemiological and animal bioassay evidence for an expanded set of ~345 PFAS that were prioritized in 2019 by the EPA’s Center for Computational Toxicology and Exposure (CCTE) for in vitro toxicity and toxicokinetic screening. This work builds upon our previously published evidence map for ~150 PFAS chemicals (Carlson et al. 2022, https://doi.org/10.1289/EHP10343). This dataset is associated with the following publication: Shirke, A., E. Radke-Farabaugh, C. Lin, R. Blain, N. Vetter, c. lemeris, p. hartman, H. Hubbard, M. Angrish, X. Arzuaga Andino, J. Congleton, J. Davis, L. Dishaw, R. Jones, R. Judson, J. Kaiser, A. Kraft, L. Lizarraga, P. Noyes, G. Patlewicz, M. Taylor, A. Williams, K. Chialton, and L. Carlson. Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 132(2): CID: 026001, (2024).
distribution	[ { "title": "https://hawc.epa.gov/assessment/100500256/", "accessURL": "https://hawc.epa.gov/assessment/100500256/" }, { "title": "https://heronet.epa.gov/heronet/index.cfm/project/page/project_id/2875", "accessURL": "https://heronet.epa.gov/heronet/index.cfm/project/page/project_id/2875" }, { "title": "https://heronet.epa.gov/heronet/index.cfm/project/page/project_id/2877", "accessURL": "https://heronet.epa.gov/heronet/index.cfm/project/page/project_id/2877" }, { "title": "https://public.tableau.com/app/profile/literature.inventory/viz/ComprehensivePFASEvidenceMapVisualizations/AnimalStudies", "accessURL": "https://public.tableau.com/app/profile/literature.inventory/viz/ComprehensivePFASEvidenceMapVisualizations/AnimalStudies" }, { "title": "https://public.tableau.com/app/profile/literature.inventory/viz/ExpandedPFASEvidenceMapVisualizations/ReadMe", "accessURL": "https://public.tableau.com/app/profile/literature.inventory/viz/ExpandedPFASEvidenceMapVisualizations/ReadMe" }, { "title": "Expanded PFAS SEM_Supplemental Excel File.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528783/Expanded%20PFAS%20SEM_Supplemental%20Excel%20File.xlsx" }, { "title": "Expanded PFAS SEM_Supplemental Material.docx", "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528783/Expanded%20PFAS%20SEM_Supplemental%20Material.docx" } ]
identifier	https://doi.org/10.23719/1528783
keyword	[ "Environmental Justice", "PFAS", "hazard identification", "per and polyfluoroaklyl substance", "systematic review" ]
license	https://pasteur.epa.gov/license/sciencehub-license.html
modified	2023-04-18
programCode	[ "020:000" ]
publisher	{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } }
references	[ "https://doi.org/10.1289/ehp13423", "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846678" ]
rights	null
title	Expanded ORD PFAS SEM