Expression of interleukin-18 receptor in fibroblast-like synoviocytes
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R α-chain and β-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA.
Complete Metadata
| @type | dcat:Dataset |
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[
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| description | An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R α-chain and β-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA. |
| distribution |
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"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
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|
| identifier | https://healthdata.gov/api/views/rxdp-m9n5 |
| issued | 2025-07-14 |
| keyword |
[
"fibroblast-synoviocytes",
"il-18-receptor",
"nih",
"rheumatoid-arthritis",
"synovial-inflammation"
]
|
| landingPage | https://healthdata.gov/d/rxdp-m9n5 |
| modified | 2025-09-06 |
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"009:037"
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| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
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| theme |
[
"NIH"
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|
| title | Expression of interleukin-18 receptor in fibroblast-like synoviocytes |
