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Flt3+macrophage precursors commit sequentially to osteoclasts, dendritic cells and microglia

Published by National Institutes of Health | U.S. Department of Health & Human Services | Metadata Last Checked: September 29, 2025 | Last Modified: 2025-09-29
Macrophages, osteoclasts, dendritic cells, and microglia are highly specialized cells that belong to the mononuclear phagocyte system. Functional and phenotypic heterogeneity within the mononuclear phagocyte system may reveal differentiation plasticity of a common progenitor, but developmental pathways leading to such diversity are still unclear.

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