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Glucocorticoid Ligand Mixtures Bioassay 2

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: August 02, 2025 | Last Modified: 2018-08-22
Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).

Resources

21 resources available

  • 170630 hGR, Prednisone, raw.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex Curve, 21-hydroxyprogesterone 2-10-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and 21-hydroxyprogesterone 4-27-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and fluticasone propionate 3-16-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and fluticasone propionate 3-30-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and fluticasone propionate 3-9-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and fluticasone propionate 4-27-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and hydrocortisone 6-15-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and hydrocortisone 6-8-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and prednisolone 2-16-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and prednisolone 3-16-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and prednisolone 3-2-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and prednisone 6-22-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and prednisone 7-7-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and triamcinalone 3-16-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and triamcinalone 3-23-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR Dex and triamcinalone 3-30-2017.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • CV1a-hGR dex and mif 1pM dex 4-20-2017.xlsx

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  • CV1a-hGR dex and mif 1pM dex 4-27-2017.xlsx

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  • CV1a-hGR dex and mif 1pM dex 5-4-2017.xlsx

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  • Data Dictionary.pdf

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Complete Metadata
accessLevel public
bureauCode 
                                            [
  "020:00"
]
contactPoint 
                                            {
  "fn": "Elizabeth Medlock Kakaley",
  "hasEmail": "mailto:medlockkakaley.elizabeth@epa.gov"
}
description Raw data for glucocorticoid receptor ligand exposure experiments. This dataset is associated with the following publication: MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, and V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 252-263, (2019).
distribution 
                                            [
  {
    "title": "170630 hGR, Prednisone, raw.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/170630%20hGR%2C%20Prednisone%2C%20raw.xlsx"
  },
  {
    "title": "CV1a-hGR Dex Curve, 21-hydroxyprogesterone 2-10-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20Curve%2C%2021-hydroxyprogesterone%202-10-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and 21-hydroxyprogesterone 4-27-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%2021-hydroxyprogesterone%204-27-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and fluticasone propionate 3-16-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20fluticasone%20propionate%203-16-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and fluticasone propionate 3-30-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20fluticasone%20propionate%203-30-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and fluticasone propionate 3-9-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20fluticasone%20propionate%203-9-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and fluticasone propionate 4-27-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20fluticasone%20propionate%204-27-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and hydrocortisone 6-15-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20hydrocortisone%206-15-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and hydrocortisone 6-8-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20hydrocortisone%206-8-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and prednisolone 2-16-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20prednisolone%202-16-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and prednisolone 3-16-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20prednisolone%203-16-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and prednisolone 3-2-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20prednisolone%203-2-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and prednisone 6-22-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20prednisone%206-22-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and prednisone 7-7-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20prednisone%207-7-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and triamcinalone 3-16-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20triamcinalone%203-16-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and triamcinalone 3-23-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20triamcinalone%203-23-2017.xlsx"
  },
  {
    "title": "CV1a-hGR Dex and triamcinalone 3-30-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20Dex%20and%20triamcinalone%203-30-2017.xlsx"
  },
  {
    "title": "CV1a-hGR dex and mif 1pM dex 4-20-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20dex%20and%20mif%201pM%20dex%204-20-2017.xlsx"
  },
  {
    "title": "CV1a-hGR dex and mif 1pM dex 4-27-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20dex%20and%20mif%201pM%20dex%204-27-2017.xlsx"
  },
  {
    "title": "CV1a-hGR dex and mif 1pM dex 5-4-2017.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/CV1a-hGR%20dex%20and%20mif%201pM%20dex%205-4-2017.xlsx"
  },
  {
    "title": "Data Dictionary.pdf",
    "mediaType": "application/pdf",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1502579/Data%20Dictionary.pdf"
  }
]
identifier https://doi.org/10.23719/1502579
keyword 
                                            [
  "chemical mixtures",
  "effects-based screening",
  "generalized concentration addition model",
  "glucocorticoid receptor",
  "partial agonist"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2018-08-22
programCode 
                                            [
  "020:096"
]
publisher 
                                            {
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
                                            [
  "https://doi.org/10.1093/toxsci/kfy290"
]
rights 
                                            null
title Glucocorticoid Ligand Mixtures Bioassay 2

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