IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus?
Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months of age, most female transgenics develop a lupus-like syndrome characterised by production of IgG anti-dsDNA, antihistone and antinucleosome autoantibodies. The autoantibodies are nephritogenic, with one-third of females developing a severe immune complex mediated glomerulonephritis. Analysis of these transgenics suggests that pathogenic autoantibodies arise via an antigen-driven T-cell-dependent mechanism with apoptotic keratinocytes acting as a potential source of autoantigen. The mechanism of autoantibody production in IFN-γ transgenics may be relevant to human lupus and is consistent with a central role for cutaneous T cells in the pathogenesis of systemic lupus erythematosus in man.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
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[
"009:25"
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{
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|
| description | Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months of age, most female transgenics develop a lupus-like syndrome characterised by production of IgG anti-dsDNA, antihistone and antinucleosome autoantibodies. The autoantibodies are nephritogenic, with one-third of females developing a severe immune complex mediated glomerulonephritis. Analysis of these transgenics suggests that pathogenic autoantibodies arise via an antigen-driven T-cell-dependent mechanism with apoptotic keratinocytes acting as a potential source of autoantigen. The mechanism of autoantibody production in IFN-γ transgenics may be relevant to human lupus and is consistent with a central role for cutaneous T cells in the pathogenesis of systemic lupus erythematosus in man. |
| distribution |
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|
| identifier | https://healthdata.gov/api/views/ghfc-umtp |
| issued | 2025-07-14 |
| keyword |
[
"autoantibodies",
"ifn-gamma",
"nih",
"systemic-lupus-erythematosus",
"transgenic-mice"
]
|
| landingPage | https://healthdata.gov/d/ghfc-umtp |
| modified | 2025-09-06 |
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"009:033"
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|
| publisher |
{
"name": "National Institutes of Health",
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}
|
| theme |
[
"NIH"
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|
| title | IFN-gamma transgenic mice: clues to the pathogenesis of systemic lupus erythematosus? |
