IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA.
Complete Metadata
| @type | dcat:Dataset |
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| accessLevel | public |
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[
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| description | The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA. |
| distribution |
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| identifier | https://healthdata.gov/api/views/qs7k-hewf |
| issued | 2025-07-13 |
| keyword |
[
"bone-resorption",
"il-17-cytokine",
"joint-degradation",
"nih",
"rheumatoid-arthritis"
]
|
| landingPage | https://healthdata.gov/d/qs7k-hewf |
| modified | 2025-09-06 |
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|
| publisher |
{
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| theme |
[
"NIH"
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|
| title | IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis |
