Improved analytical methods for microarray-based genome-composition analysis
Genome-composition analysis using microarrays can be used to categorize genes into 'present' and 'divergent' categories. This involves selecting a signal value that is used as a cutoff to discriminate present and divergent genes, but this can result in the misclassification of many genes. A method is described that depends on the shape of the signal-ratio distribution and does not require empirical determination of a cutoff. Many genes previously classified as present using static methods are in fact divergent on the basis of microarray signal; this is corrected by our algorithm.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
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|
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{
"fn": "NIH",
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"hasEmail": "mailto:info@nih.gov"
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|
| description | Genome-composition analysis using microarrays can be used to categorize genes into 'present' and 'divergent' categories. This involves selecting a signal value that is used as a cutoff to discriminate present and divergent genes, but this can result in the misclassification of many genes. A method is described that depends on the shape of the signal-ratio distribution and does not require empirical determination of a cutoff. Many genes previously classified as present using static methods are in fact divergent on the basis of microarray signal; this is corrected by our algorithm. |
| distribution |
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"title": "Official Government Data Source",
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"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133449/"
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|
| identifier | https://healthdata.gov/api/views/qnv3-adab |
| issued | 2025-07-14 |
| keyword |
[
"gene-expression",
"genome-composition",
"genomic-research",
"microarray-analysis",
"nih"
]
|
| landingPage | https://healthdata.gov/d/qnv3-adab |
| modified | 2025-09-06 |
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"009:048"
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|
| publisher |
{
"name": "National Institutes of Health",
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|
| theme |
[
"NIH"
]
|
| title | Improved analytical methods for microarray-based genome-composition analysis |
