IN VITRO AND IN VIVO ANDROGEN RECEPTOR DATA SET FROM TOX SCI PAPER GRAY ET AL 2020
Data sets include
1. Excel file with Hershberger assay protocols and data and summaries of in vivo antiandrogen studies
2. Figures of in vitro AR assay results from contract work and in house studies
3. Excel file with in house in vitro AR antagonism data.
This dataset is associated with the following publication:
Gray, L., J. Furr, C. Lambright, N. Evans, P. Hartig, M. Cardon, V. Wilson, A. Hotchkiss, and J. Conley. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(2): 297-311, (2020).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Leon Gray",
"hasEmail": "mailto:gray.earl@epa.gov"
}
|
| description | Data sets include 1. Excel file with Hershberger assay protocols and data and summaries of in vivo antiandrogen studies 2. Figures of in vitro AR assay results from contract work and in house studies 3. Excel file with in house in vitro AR antagonism data. This dataset is associated with the following publication: Gray, L., J. Furr, C. Lambright, N. Evans, P. Hartig, M. Cardon, V. Wilson, A. Hotchkiss, and J. Conley. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(2): 297-311, (2020). |
| distribution |
[
{
"title": "AR phase 1 2 and 3 ED50 and binding ceetox figures.pdf",
"mediaType": "application/pdf",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520150/AR%20%20phase%201%202%20%20and%203%20ED50%20and%20binding%20ceetox%20figures.pdf"
},
{
"title": "DR VS WILSON 2010 SOT POSTER WITH IN VITRO ANDROGEN RECEPTOR DATA.pdf",
"mediaType": "application/pdf",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520150/DR%20VS%20WILSON%202010%20SOT%20POSTER%20WITH%20IN%20VITRO%20ANDROGEN%20RECEPTOR%20DATA.pdf"
},
{
"title": "OUR HERSHBERGER STUDIES FOR SCIENCE HUB.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520150/OUR%20HERSHBERGER%20STUDIES%20FOR%20SCIENCE%20HUB.xlsx"
},
{
"title": "mda kb2 and CV-1 transduction Antagonists and antagonists data from RTB Team FOR SCIENCE HUB.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520150/mda%20kb2%20and%20CV-1%20transduction%20%20Antagonists%20and%20antagonists%20data%20from%20RTB%20Team%20FOR%20SCIENCE%20HUB.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1520150 |
| keyword |
[
"Androgen receptor",
"Hershberger assay",
"antiandrogens",
"in utero effects on male reproductive development",
"in vitro in vivo extrapolation",
"quantitative AOP for Androgen Receptor Antagonistsr"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2020-10-22 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfaa067"
]
|
| rights |
null
|
| title | IN VITRO AND IN VIVO ANDROGEN RECEPTOR DATA SET FROM TOX SCI PAPER GRAY ET AL 2020 |
