Interleukin-4 receptor alpha gene variants and allergic disease
The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor α (IL-4Rα) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Rα polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
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[
"009:25"
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| description | The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor α (IL-4Rα) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Rα polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme. |
| distribution |
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|
| identifier | https://healthdata.gov/api/views/ctnr-ernd |
| issued | 2025-07-14 |
| keyword |
[
"asthma-genetics",
"atopic-disease",
"genetic-variants",
"il-4-receptor",
"nih"
]
|
| landingPage | https://healthdata.gov/d/ctnr-ernd |
| modified | 2025-09-06 |
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"009:033"
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|
| publisher |
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|
| theme |
[
"NIH"
]
|
| title | Interleukin-4 receptor alpha gene variants and allergic disease |
