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LacI protein genotype-phenotype landscape data
This data table contains the processed data for the LacI genotype-phenotype landscape, a quantitative measurement of the phenotype for approximately 60,000 variants of the E. coli LacI protein. The table includes, for example, the DNA barcode sequencing counts and the estimated fitness for each variant across 24 different chemical environments. It also includes the estimated dose-response curves for each variant under induction with IPTG.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| accrualPeriodicity | irregular |
| bureauCode |
[
"006:55"
]
|
| contactPoint |
{
"fn": "David J. Ross",
"hasEmail": "mailto:david.ross@nist.gov"
}
|
| description | This data table contains the processed data for the LacI genotype-phenotype landscape, a quantitative measurement of the phenotype for approximately 60,000 variants of the E. coli LacI protein. The table includes, for example, the DNA barcode sequencing counts and the estimated fitness for each variant across 24 different chemical environments. It also includes the estimated dose-response curves for each variant under induction with IPTG. |
| distribution |
[
{
"title": "DOI Access for LacI protein genotype-phenotype landscape data",
"accessURL": "https://doi.org/10.18434/M32259"
},
{
"mediaType": "application/octet-stream",
"downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2259/Example%20code_Open%20LacI%20Data%20Table.ipynb"
},
{
"mediaType": "text/plain",
"downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2259/Example%20code_Open%20LacI%20Data%20Table.ipynb.sha256"
},
{
"mediaType": "text/csv",
"downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data%20columns%20description.csv"
},
{
"mediaType": "text/plain",
"downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data%20columns%20description.csv.sha256"
},
{
"title": "Lacl landscape data",
"mediaType": "application/x-hdf",
"downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data.hdf"
},
{
"mediaType": "text/plain",
"downloadURL": "https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data.hdf.sha256"
}
]
|
| identifier | ark:/88434/mds2-2259 |
| issued | 2020-07-10 |
| keyword |
[
"DNA barcode sequencing",
"E. coli",
"Lac repressor",
"allostery",
"engineering biology",
"fitness landscape",
"genotype-phenotype relationships"
]
|
| landingPage | https://data.nist.gov/od/id/mds2-2259 |
| language |
[
"en"
]
|
| license | https://www.nist.gov/open/license |
| modified | 2020-06-30 00:00:00 |
| programCode |
[
"006:045"
]
|
| publisher |
{
"name": "National Institute of Standards and Technology",
"@type": "org:Organization"
}
|
| theme |
[
"Bioscience:Cell biology",
"Bioscience:Engineering/synthetic biology",
"Bioscience:Proteomics"
]
|
| title | LacI protein genotype-phenotype landscape data |
