Return to search results
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection
To reveal outcomes of microgravity on molecular processes within the cellular environment we have employed a mass-spectrometry based proteomics approach. Proteomics analysis based on mass spectrometry allows for the relative quantitation of a large number of proteins concurrently, and in a relatively unbiased manner. Mass spectrometry based proteomics can be rendered even more informative by addition of a labeling component to understand the dynamics of the changing protein content. In this study, we utilized a combination of proteomics techniques, namely label-free quantification and dynamic stable-isotope labeling by amino acids in cell culture (Dynamic SILAC) to characterize the microgravity stress response in primary cardiomyocytes.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"026:00"
]
|
| contactPoint |
{
"fn": "Open Science Data Repository Help Desk",
"@type": "vcard:Contact",
"hasEmail": "mailto:arc-dl-osdr-help@mail.nasa.gov"
}
|
| description | To reveal outcomes of microgravity on molecular processes within the cellular environment we have employed a mass-spectrometry based proteomics approach. Proteomics analysis based on mass spectrometry allows for the relative quantitation of a large number of proteins concurrently, and in a relatively unbiased manner. Mass spectrometry based proteomics can be rendered even more informative by addition of a labeling component to understand the dynamics of the changing protein content. In this study, we utilized a combination of proteomics techniques, namely label-free quantification and dynamic stable-isotope labeling by amino acids in cell culture (Dynamic SILAC) to characterize the microgravity stress response in primary cardiomyocytes. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Data Information (Unknown Format)",
"format": "BIN",
"mediaType": "application/octet-stream",
"downloadURL": "https://lsda.jsc.nasa.gov/scripts/experiment/exper.aspx?exp_index=2093"
},
{
"@type": "dcat:Distribution",
"title": "Download (Data)",
"format": "BIN",
"mediaType": "application/octet-stream",
"downloadURL": "https://osdr.nasa.gov/bio/repo/data/studies/OSD-122"
}
]
|
| identifier | 10.26030/j21n-tx59 |
| keyword |
[
"na"
]
|
| modified | 2025-08-21 |
| programCode |
[
"026:000"
]
|
| publisher |
{
"name": "Open Science Data Repository",
"@type": "org:Organization"
}
|
| theme |
[
"Biological and Physical Sciences"
]
|
| title | Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection |
