Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats
This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis (AIA) in the rat knee. In the acute phase of AIA, which was characterized by pronounced hyperalgesia, there was a substantial bilateral increase in the proportion of lumbar DRG neurons that express neurokinin 1 receptors (activated by substance P) and bradykinin 2 receptors. In the chronic phase the upregulation of bradykinin 2 receptors persisted on the side of inflammation. The increase in the receptor expression is relevant for the generation of acute and chronic inflammatory pain.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
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"fn": "NIH",
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|
| description | This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis (AIA) in the rat knee. In the acute phase of AIA, which was characterized by pronounced hyperalgesia, there was a substantial bilateral increase in the proportion of lumbar DRG neurons that express neurokinin 1 receptors (activated by substance P) and bradykinin 2 receptors. In the chronic phase the upregulation of bradykinin 2 receptors persisted on the side of inflammation. The increase in the receptor expression is relevant for the generation of acute and chronic inflammatory pain. |
| distribution |
[
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"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
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"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC17819/"
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|
| identifier | https://healthdata.gov/api/views/4eps-sfj2 |
| issued | 2025-07-13 |
| keyword |
[
"antigen-induced-arthritis",
"dorsal-root-ganglion",
"inflammatory-pain",
"neurokinin-receptors",
"nih"
]
|
| landingPage | https://healthdata.gov/d/4eps-sfj2 |
| modified | 2025-09-06 |
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| publisher |
{
"name": "National Institutes of Health",
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| theme |
[
"NIH"
]
|
| title | Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats |
