Patent AT-E399769-T1: [Translated] SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE
The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
Complete Metadata
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| accessLevel | public |
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| description | The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% <SMALLCAPS>L</SMALLCAPS>-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use. |
| distribution |
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"description": "Access the complete Patent AT-E399769-T1: [Translated] SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE on the official website.",
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|
| identifier | https://healthdata.gov/api/views/mpr6-2kbk |
| issued | 2025-09-05 |
| keyword |
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| modified | 2025-09-06 |
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| publisher |
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| theme |
[
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| title | Patent AT-E399769-T1: [Translated] SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE |
