Patent AT-E400293-T1: [Translated] SIGNAL-1/SIGNAL-2 BIFUNCTIONAL PEPTIDE INHIBITORS
A novel peptide sequence having the general formula AB wherein each of A and B represent a chain of amino acid residues and wherein said A chain is capable of binding with a mojor histocompatibility comples on an antigen presenting cell, and wherein said B chain is capable of binding wiht a Signal-2 receptor on an antigen presenting cell. Preferred forms of the peptide sequence further include and Y chain positioned intermediate the A chain and the B chain. Moreover, preferred forms include and A chain which has at least about 10% sequence homology with a Signal-1 moiety, or is a peptidomimetic of a Signal-1 moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, or is a peptidomimetic of a Signal-2 receptpr moiety, and wherein the X chain has at least one amino acid residue, or is a peptidomimetic of that amino acid residue. Advantageously, the movel peptide sequence is capable of shifting a type-1 immune response to a type-2 immune response or from a type-2 immune response to a type-1 immune response.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
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{
"fn": "NIH/NCBI Data Team",
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"hasEmail": "mailto:info@ncbi.nlm.nih.gov"
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|
| description | A novel peptide sequence having the general formula AB wherein each of A and B represent a chain of amino acid residues and wherein said A chain is capable of binding with a mojor histocompatibility comples on an antigen presenting cell, and wherein said B chain is capable of binding wiht a Signal-2 receptor on an antigen presenting cell. Preferred forms of the peptide sequence further include and Y chain positioned intermediate the A chain and the B chain. Moreover, preferred forms include and A chain which has at least about 10% sequence homology with a Signal-1 moiety, or is a peptidomimetic of a Signal-1 moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, or is a peptidomimetic of a Signal-2 receptpr moiety, and wherein the X chain has at least one amino acid residue, or is a peptidomimetic of that amino acid residue. Advantageously, the movel peptide sequence is capable of shifting a type-1 immune response to a type-2 immune response or from a type-2 immune response to a type-1 immune response. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Data Source",
"mediaType": "text/html",
"description": "Access the complete Patent AT-E400293-T1: [Translated] SIGNAL-1/SIGNAL-2 BIFUNCTIONAL PEPTIDE INHIBITORS on the official website.",
"downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E400293-T1"
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|
| identifier | https://healthdata.gov/api/views/qs54-r6ha |
| issued | 2025-09-05 |
| keyword |
[
"chemistry",
"innovation",
"patent",
"pubchem",
"research"
]
|
| landingPage | https://healthdata.gov/d/qs54-r6ha |
| modified | 2025-09-06 |
| programCode |
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"009:066"
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|
| publisher |
{
"name": "National Center for Biotechnology Information (NCBI)",
"@type": "org:Organization"
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|
| theme |
[
"NIH"
]
|
| title | Patent AT-E400293-T1: [Translated] SIGNAL-1/SIGNAL-2 BIFUNCTIONAL PEPTIDE INHIBITORS |
