Patent AT-E400579-T1: [Translated] METHOD FOR SEPARATING EXOCYCLIC BASE PROTECTION GROUPS
Nitrogen-protecting groups are removed from the exocyclic nucleobase portion of a 2′-O protected nucleotide or 2′-halo nucleotide by contacting the nucleotide with an inorganic base. Typical is the removal of t-butylphenoxyacetyl protecting groups from the nucleobase portion of a 2′-O protected nucleotide on which the 2′-O protecting group is t-butyldimethylsilyl, removal or deprotection being accomplished by contact with a potassium carbonate solution.
Complete Metadata
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| description | Nitrogen-protecting groups are removed from the exocyclic nucleobase portion of a 2′-O protected nucleotide or 2′-halo nucleotide by contacting the nucleotide with an inorganic base. Typical is the removal of t-butylphenoxyacetyl protecting groups from the nucleobase portion of a 2′-O protected nucleotide on which the 2′-O protecting group is t-butyldimethylsilyl, removal or deprotection being accomplished by contact with a potassium carbonate solution. |
| distribution |
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| identifier | https://healthdata.gov/api/views/qq9t-3yii |
| issued | 2025-09-05 |
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| modified | 2025-09-06 |
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| theme |
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| title | Patent AT-E400579-T1: [Translated] METHOD FOR SEPARATING EXOCYCLIC BASE PROTECTION GROUPS |
