Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE.
Disclosed herein are tetrahydro-benzo [e] isoindolines useful in the treatment of hypertension, which are represented by the formula wherein R, R1, and R2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, benzyloxy, benzoyloxy, thiomethyl, halo, or wherein R4 and R5 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula wherein R6 is loweralkyl of 1 to 4 carbon atoms; or R and R1, or R1 and R2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R1 or R2 must be other than hydrogen; and R3 is hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula wherein m is 0, 1 or 2, p is 0 or 1, R7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R8 and R9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1 to 4 carbon atoms, or halo, or R8 and R9 can be taken together to form a methylendioxy or ethylenedioxy bridge; or 1,4-benzodioxan.
Complete Metadata
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| description | Disclosed herein are tetrahydro-benzo [e] isoindolines useful in the treatment of hypertension, which are represented by the formula <CHEM> wherein R, R1, and R2 are independently selected from hydrogen, hydroxy, loweralkoxy of 1 to 3 carbon atoms, loweralkenyloxy of 1 to 3 carbon atoms, benzyloxy, benzoyloxy, thiomethyl, halo, or <CHEM> wherein R4 and R5 are independently selected from hydrogen, loweracyl of 1 to 4 carbon atoms or sulfonyl of the formula <CHEM> wherein R6 is loweralkyl of 1 to 4 carbon atoms; or R and R1, or R1 and R2 can be taken together to form a methylenedioxy or ethylenedioxy bridge; with the proviso that at least one of R, R1 or R2 must be other than hydrogen; and R3 is hydrogen; loweralkyl of 1 to 4 carbon atoms; halo-substituted loweralkyl of 1 to 4 carbon atoms; arylalkyl of the formula <CHEM> wherein m is 0, 1 or 2, p is 0 or 1, R7 is hydrogen or loweralkyl of 1 to 4 carbon atoms and R8 and R9 are independently selected from hydrogen, hydroxy, methoxy, loweralkyl of 1 to 4 carbon atoms, or halo, or R8 and R9 can be taken together to form a methylendioxy or ethylenedioxy bridge; or 1,4-benzodioxan. |
| distribution |
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{
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"title": "Official Data Source",
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"description": "Access the complete Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE. on the official website.",
"downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E40115-T1"
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| identifier | https://healthdata.gov/api/views/duwj-qgb5 |
| issued | 2025-09-05 |
| keyword |
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"chemistry",
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| landingPage | https://healthdata.gov/d/duwj-qgb5 |
| modified | 2025-09-06 |
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| publisher |
{
"name": "National Center for Biotechnology Information (NCBI)",
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| theme |
[
"NIH"
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| title | Patent AT-E40115-T1: [Translated] TETRAHYDRO-BENZO (E) ISOINDOLINE. |
