Patent AT-E401345-T1: [Translated] SYNTHETIC MIMETICS OF PHYSIOLOGICAL BINDING MOLECULES
A binding molecule comprising a support structure of at least one cyclic molecular subunit and at least two side chain subunits, where the side chain subunits are polypeptide chains containing natural and/or unnatural D- and/or L-amino acids and/or polynucleotide chains, and are covalently bonded to the support structure, is new. Independent claims are also included for: (1) preparing the binding molecule using solid phase synthesis, where the method comprises binding the peptide of the side chain subunit to the solid phase, extending the amino acids and optionally coupling to the support structure; (2) peptide of sequence (Ia) or (Ib), where the side chain subunits have sequence homology of at least 80 %; and (3) a pharmaceutical comprising the binding molecule and/or peptide. Ala-Pro-Thr-Ser-Ser-Ser-Thr-Lys-Lys-T1-Gln-Leu-Gln-Leu-Glu-His-X1-X2-X3-X4-X5-Gln-Met-Ile-Leu-Asn-Gly-Ile-Asn-Asn (Ia); Thr-Ile-Val-X6-Phe-Leu-Asn-Arg-Trp-Ile-Thr-Phe-X7-Gln-Ser-X8-Ile-Ser-Thr-Leu-T1 (Ib). X1 and X2 = Ile or Leu; X3 = Val, Leu or Met; X4 = Glu, Asp or Lys; X5 = Leu or Phe; X6 = Glu or Asp; X7 = Ala, Gly or Cys; X8 = Ala or Ile; and T1 = Thr.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
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"fn": "NIH/NCBI Data Team",
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"hasEmail": "mailto:info@ncbi.nlm.nih.gov"
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|
| description | A binding molecule comprising a support structure of at least one cyclic molecular subunit and at least two side chain subunits, where the side chain subunits are polypeptide chains containing natural and/or unnatural D- and/or L-amino acids and/or polynucleotide chains, and are covalently bonded to the support structure, is new. Independent claims are also included for: (1) preparing the binding molecule using solid phase synthesis, where the method comprises binding the peptide of the side chain subunit to the solid phase, extending the amino acids and optionally coupling to the support structure; (2) peptide of sequence (Ia) or (Ib), where the side chain subunits have sequence homology of at least 80 %; and (3) a pharmaceutical comprising the binding molecule and/or peptide. Ala-Pro-Thr-Ser-Ser-Ser-Thr-Lys-Lys-T1-Gln-Leu-Gln-Leu-Glu-His-X1-X2-X3-X4-X5-Gln-Met-Ile-Leu-Asn-Gly-Ile-Asn-Asn (Ia); Thr-Ile-Val-X6-Phe-Leu-Asn-Arg-Trp-Ile-Thr-Phe-X7-Gln-Ser-X8-Ile-Ser-Thr-Leu-T1 (Ib). X1 and X2 = Ile or Leu; X3 = Val, Leu or Met; X4 = Glu, Asp or Lys; X5 = Leu or Phe; X6 = Glu or Asp; X7 = Ala, Gly or Cys; X8 = Ala or Ile; and T1 = Thr. |
| distribution |
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{
"@type": "dcat:Distribution",
"title": "Official Data Source",
"mediaType": "text/html",
"description": "Access the complete Patent AT-E401345-T1: [Translated] SYNTHETIC MIMETICS OF PHYSIOLOGICAL BINDING MOLECULES on the official website.",
"downloadURL": "https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401345-T1"
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|
| identifier | https://healthdata.gov/api/views/u39h-amxr |
| issued | 2025-09-05 |
| keyword |
[
"chemistry",
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| landingPage | https://healthdata.gov/d/u39h-amxr |
| modified | 2025-09-06 |
| programCode |
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| publisher |
{
"name": "National Center for Biotechnology Information (NCBI)",
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|
| theme |
[
"NIH"
]
|
| title | Patent AT-E401345-T1: [Translated] SYNTHETIC MIMETICS OF PHYSIOLOGICAL BINDING MOLECULES |
