Patent AT-E401394-T1: [Translated] IMPROVED DNASE LIQUID SOLUTIONS
The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions having a pH of less than neutral. DNase is the active pharmaceutical principle and the solutions may contain other pharmaceutically acceptable excipients making them suitable for pharmaceutical administration. In the first instance, calcium ion/sugar minimizes the effects of thermal aggregation in the solution. In the second aspect, calcium ion stabilizes the lower pH solutions from protein precipitation.
Complete Metadata
| bureauCode |
[ "009:25" ] |
|---|---|
| identifier | https://healthdata.gov/api/views/fkft-s9kd |
| issued | 2025-09-05 |
| landingPage | https://healthdata.gov/d/fkft-s9kd |
| programCode |
[ "009:066" ] |
| theme |
[ "NIH" ] |
