Patent AT-E401402-T1: [Translated] PROTEINS INTERACTING WITH SYNDEKAN AND THEIR USE
The invention relates to the identification of a new protein that binds to the cytoplasmic domain of syndecan. This new protein, denominated as "syntenin", contains 298 amino acids and is characterized by a tandem repeat of PDZ-domains that reacts with the C-terminal amino acid sequence of syndecans. The amino-terminal region of syntenin further comprises five tyrosine residues whereas no tyrosine residues are present in the remaining part of the protein. The present invention further discloses a nucleic acid encoding syntenin, a method to screen for components interfering with the syndecan-syntenin interaction, a method for diagnosing Alzheimer's disease, inflammatory diseases, and malignancies and a pharmaceutical composition for healing the latter diseases.
Complete Metadata
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| accessLevel | public |
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| description | The invention relates to the identification of a new protein that binds to the cytoplasmic domain of syndecan. This new protein, denominated as "syntenin", contains 298 amino acids and is characterized by a tandem repeat of PDZ-domains that reacts with the C-terminal amino acid sequence of syndecans. The amino-terminal region of syntenin further comprises five tyrosine residues whereas no tyrosine residues are present in the remaining part of the protein. The present invention further discloses a nucleic acid encoding syntenin, a method to screen for components interfering with the syndecan-syntenin interaction, a method for diagnosing Alzheimer's disease, inflammatory diseases, and malignancies and a pharmaceutical composition for healing the latter diseases. |
| distribution |
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"description": "Access the complete Patent AT-E401402-T1: [Translated] PROTEINS INTERACTING WITH SYNDEKAN AND THEIR USE on the official website.",
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| identifier | https://healthdata.gov/api/views/2y9g-th3y |
| issued | 2025-09-05 |
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| landingPage | https://healthdata.gov/d/2y9g-th3y |
| modified | 2025-09-06 |
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| publisher |
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| theme |
[
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| title | Patent AT-E401402-T1: [Translated] PROTEINS INTERACTING WITH SYNDEKAN AND THEIR USE |
