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PFAS in vitro data set
Results of single concentration and concentration response testing of 165 PFAS samples from the USEPA ToxCast chemical library in nine (9) thyroid relevant assays. Chemicals were first screened in single concentration ('Single Concentration' tab) and then those chemicals with 50% or greater activity were further tested in concentration-response mode ('Concentration Response' tab).
This dataset is associated with the following publication:
Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, J. Haselman, S. Mayasich, and M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 95: 105762, (2024).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Sigmund Degitz",
"hasEmail": "mailto:degitz.sigmund@epa.gov"
}
|
| description | Results of single concentration and concentration response testing of 165 PFAS samples from the USEPA ToxCast chemical library in nine (9) thyroid relevant assays. Chemicals were first screened in single concentration ('Single Concentration' tab) and then those chemicals with 50% or greater activity were further tested in concentration-response mode ('Concentration Response' tab). This dataset is associated with the following publication: Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, J. Haselman, S. Mayasich, and M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, USA, 95: 105762, (2024). |
| distribution |
[
{
"title": "Degitz_Thyroid_PFAS screening_230203.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528672/Degitz_Thyroid_PFAS%20screening_230203.xlsx"
}
]
|
| identifier | https://doi.org/10.23719/1528672 |
| keyword |
[
"PFAS"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2023-02-03 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.tiv.2023.105762"
]
|
| rights |
null
|
| title | PFAS in vitro data set |
