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Reproducibility of organ-level effects in repeat dose animal studies
This work estimates benchmarks for new approach method (NAM) performance in predicting organ-level effects in repeat dose studies of adult animals based on variability in replicate animal studies. Data for Paul Friedman et al., ‘Reproducibility of organ-level effects in repeat dose animal studies’, Computational Toxicology, Vol 28, 100287, Nov 2023, https://doi.org/10.1016/j.comtox.2023.100287.
This dataset is associated with the following publication:
Friedman, K., M. Foster, L.L. Pham, M. Feshuk, S. Watford, J. Wambaugh, R. Judson, R. Setzer, and R. Thomas. Reproducibility of organ-level effects in repeat dose animal studies. Computational Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 28: 100287, (2023).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Katie Friedman",
"hasEmail": "mailto:paul-friedman.katie@epa.gov"
}
|
| description | This work estimates benchmarks for new approach method (NAM) performance in predicting organ-level effects in repeat dose studies of adult animals based on variability in replicate animal studies. Data for Paul Friedman et al., ‘Reproducibility of organ-level effects in repeat dose animal studies’, Computational Toxicology, Vol 28, 100287, Nov 2023, https://doi.org/10.1016/j.comtox.2023.100287. This dataset is associated with the following publication: Friedman, K., M. Foster, L.L. Pham, M. Feshuk, S. Watford, J. Wambaugh, R. Judson, R. Setzer, and R. Thomas. Reproducibility of organ-level effects in repeat dose animal studies. Computational Toxicology. Elsevier B.V., Amsterdam, NETHERLANDS, 28: 100287, (2023). |
| distribution |
[
{
"title": "https://clowder.edap-cluster.com/datasets/646d247fe4b08a6b394d2853",
"accessURL": "https://clowder.edap-cluster.com/datasets/646d247fe4b08a6b394d2853"
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{
"title": "https://github.com/USEPA/CompTox-Reproducibility-Organ-Effects",
"accessURL": "https://github.com/USEPA/CompTox-Reproducibility-Organ-Effects"
}
]
|
| identifier | https://doi.org/10.23719/1529446 |
| keyword |
[
"Organ",
"Repeat dose",
"ToxRefDB",
"variability"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2023-05-24 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1016/j.comtox.2023.100287"
]
|
| rights |
null
|
| title | Reproducibility of organ-level effects in repeat dose animal studies |
