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Rodent Research-1 (RR1) National Lab Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data

Published by National Aeronautics and Space Administration | National Aeronautics and Space Administration | Metadata Last Checked: August 04, 2025 | Last Modified: 2025-04-23
The Rodent Reasearch-1 National Lab (RR-1 CASIS) experiment was performed to study the effect of microgravity on muscle wasting. RNA DNA and protein were purified from nine RR-1 CASIS (the Center for the Advancement of Science in Space) liver samples. Groups included: Flight (FLT) dissected on-orbit (21 or 22 days after launch); age-matched Ground Controls (GC); and Basal Controls (BC euthanized at time of launch) with N=3/group. RNA-Seq whole genome BS-Seq (bisulfite sequencing) and proteomic expression profiling were performed.

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