Summary dataset for biomarkers, PCB congeners, and microRNAs measured in serum and associations of these data for the Anniston Community Health Survey I (ACHS-I).
These data are summaries of pro-inflammatory cytokine and insulin resistance serum biomarkers; necrotic liver disease defined by serum keratin 18 (K18) biomarkers. Associations were determined between exposure biomarkers (thirty-five ortho-substituted PCB congeners) and disease biomarkers (miRs); and Ingenuity Pathway Analysis was performed. Note to protect individual molecular information, only summaries of the data are presented.
This dataset is associated with the following publication:
Cave, M., C. Pinkston, S. Rai, B. Wahlang, M. Pavuk, K. Head, G. Carswell, G. Nelson, C. Klinge, D. Bell, L. Birnbaum, and B. Chorley. Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 130(1): 017003, (2022).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Brian Chorley",
"hasEmail": "mailto:chorley.brian@epa.gov"
}
|
| description | These data are summaries of pro-inflammatory cytokine and insulin resistance serum biomarkers; necrotic liver disease defined by serum keratin 18 (K18) biomarkers. Associations were determined between exposure biomarkers (thirty-five ortho-substituted PCB congeners) and disease biomarkers (miRs); and Ingenuity Pathway Analysis was performed. Note to protect individual molecular information, only summaries of the data are presented. This dataset is associated with the following publication: Cave, M., C. Pinkston, S. Rai, B. Wahlang, M. Pavuk, K. Head, G. Carswell, G. Nelson, C. Klinge, D. Bell, L. Birnbaum, and B. Chorley. Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 130(1): 017003, (2022). |
| distribution |
[
{
"title": "ACHS I miR Summaries + Metadata.xlsx",
"mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520775/ACHS%20I%20miR%20Summaries%20%2B%20Metadata.xlsx"
},
{
"title": "IPA miRNA analysis tox functions.xls",
"mediaType": "application/vnd.ms-excel",
"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520775/IPA%20miRNA%20analysis%20tox%20functions.xls"
}
]
|
| identifier | https://doi.org/10.23719/1520775 |
| keyword |
[
"Human Exposure",
"Polychlorinated biphenyls (PCBs)",
"biomarkers of effect",
"fatty liver disease",
"microRNAs",
"serum"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2021-02-10 |
| programCode |
[
"020:000"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1289/ehp9467"
]
|
| rights |
null
|
| title | Summary dataset for biomarkers, PCB congeners, and microRNAs measured in serum and associations of these data for the Anniston Community Health Survey I (ACHS-I). |
