The gene encoding interleukin-13: a susceptibility locus for asthma and related traits
Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
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[
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| description | Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma. Recently, the Th2 cytokine interleukin-13 has been shown to be a critical mediator of the asthma phenotype in murine models. In this commentary we discuss several recent studies that have identified polymorphisms in the gene encoding interleukin-13. The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
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"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59537/"
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|
| identifier | https://healthdata.gov/api/views/gwvd-72pg |
| issued | 2025-07-14 |
| keyword |
[
"asthma-genetics",
"atopy-susceptibility",
"chromosome-5q31",
"interleukin-13",
"nih"
]
|
| landingPage | https://healthdata.gov/d/gwvd-72pg |
| modified | 2025-09-06 |
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"009:033"
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|
| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | The gene encoding interleukin-13: a susceptibility locus for asthma and related traits |
