The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver
Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available.
This dataset is associated with the following publication:
Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021).
Complete Metadata
| accessLevel | public |
|---|---|
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[
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| contactPoint |
{
"fn": "Urmila Kodavanti",
"hasEmail": "mailto:kodavanti.urmila@epa.gov"
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|
| description | Air pollution has been associated with metabolic diseases and hepatic steatosis-like changes. We have shown that ozone alters liver gene expression for metabolic processes through neuroendocrine activation. This study aimed to further characterize ozone-induced changes and to determine the impact of hepatic vagotomy (HV) which reduces parasympathetic influence. Twelve-week-old male Wistar-Kyoto rats underwent HV or sham surgery five-six days prior to air or ozone exposure (0 or 1 ppm; 4 h/d for one or two days). Ozone-induced lung injury, hyperglycemia, glucose intolerance, circulating lipids and liver global mRNA expression were assessed. mRNA sequencing data are already made publicly available. This dataset is associated with the following publication: Colonna, C., A. Henriquez, J. House, A. Motsinger-Reif, D. Alewel, A. Fisher, H. Ren, S. Snow, M.C. Schladweiler, D. Miller, C. Miller, P.R. Kodavanti, and U. Kodavanti. The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 181(2): 229-245, (2021). |
| distribution |
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| identifier | https://doi.org/10.23719/1521265 |
| keyword |
[
"Ozone",
"Stress Response",
"cell cycle",
"fatty acid metabolism",
"glucose metabolism",
"hepatic vagotomy",
"liver mRNA sequencing"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2021-03-22 |
| programCode |
[
"020:000"
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| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
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| references |
[
"https://doi.org/10.1093/toxsci/kfab025"
]
|
| rights |
null
|
| title | The Role of Hepatic Vagal Tone in Ozone-induced Metabolic Dysfunction in the Liver |
