Tumor necrosis factor-α and muscle wasting: a cellular perspective
Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-α disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-κB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-α effects on skeletal muscle and the mechanism of TNF-α action.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
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[
"009:25"
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|
| description | Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects of TNF-α on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-α disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-κB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-α effects on skeletal muscle and the mechanism of TNF-α action. |
| distribution |
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| identifier | https://healthdata.gov/api/views/p5c4-ivk4 |
| issued | 2025-07-14 |
| keyword |
[
"muscle-wasting",
"nih",
"skeletal-muscle",
"tnf-alpha"
]
|
| landingPage | https://healthdata.gov/d/p5c4-ivk4 |
| modified | 2025-09-06 |
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| theme |
[
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|
| title | Tumor necrosis factor-α and muscle wasting: a cellular perspective |
