Why do antioxidants fail to provide clinical benefit?
The results of recent randomized trials to test the influence of antioxidants on coronary-event rates and prognosis in patients with coronary-artery disease were disappointing. In none of these studies did the use of vitamin E improve prognosis. In contrast, treatment of coronary-artery disease with angiotensin-converting-enzyme (ACE) inhibitors reduced coronary-event rates and improved prognosis. ACE inhibition prevents the formation of angiotensin II, which has been shown to be a potent stimulus of superoxide-producing enzymes in atherosclerosis. The findings suggest that inhibition of superoxide production at enzymatic levels, rather than symptomatic superoxide scavenging, may be the better choice of treatment.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
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|
| contactPoint |
{
"fn": "NIH",
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"hasEmail": "mailto:info@nih.gov"
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|
| description | The results of recent randomized trials to test the influence of antioxidants on coronary-event rates and prognosis in patients with coronary-artery disease were disappointing. In none of these studies did the use of vitamin E improve prognosis. In contrast, treatment of coronary-artery disease with angiotensin-converting-enzyme (ACE) inhibitors reduced coronary-event rates and improved prognosis. ACE inhibition prevents the formation of angiotensin II, which has been shown to be a potent stimulus of superoxide-producing enzymes in atherosclerosis. The findings suggest that inhibition of superoxide production at enzymatic levels, rather than symptomatic superoxide scavenging, may be the better choice of treatment. |
| distribution |
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{
"@type": "dcat:Distribution",
"title": "Official Government Data Source",
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"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59596/"
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|
| identifier | https://healthdata.gov/api/views/cmkf-jadg |
| issued | 2025-07-14 |
| keyword |
[
"ace-inhibitors",
"antioxidant-therapy",
"coronary-artery-disease",
"nih",
"superoxide-production"
]
|
| landingPage | https://healthdata.gov/d/cmkf-jadg |
| modified | 2025-09-06 |
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| publisher |
{
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"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | Why do antioxidants fail to provide clinical benefit? |
