Found 39 datasets matching "CD4".
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IL-10, IL-13, IFN-γ, tumor necrosis factor (TNF)-α, LT-α, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4+...
Search relevance: 146.56 | Views last month: 0 -
Background Intrathymic development and selection of the T lymphocyte repertoire is restricted by the interactions of the T cell antigen receptor and CD4 or CD8 co-receptors with self...
Search relevance: 142.24 | Views last month: 0 -
CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or IL-4 after a brief...
Search relevance: 130.82 | Views last month: 0 -
Background Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other...
Search relevance: 112.39 | Views last month: 1 -
The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies (mAbs) (with distinct epitope specifities) in the treatment of rat adjuvant arthritis (AA) and...
Search relevance: 110.59 | Views last month: 0 -
Background The function of the thymic microenvironment is to promote thymocyte maturation, in part via regulation of thymocyte proliferation and cell death. Defects in fetal thymic...
Search relevance: 109.91 | Views last month: 0 -
Twenty-four yearling Angus-dairy cross heifers were housed in an outdoor facility at the National Animal Disease Center (NADC) in Ames, Iowa. Heifers were vaccinated subcutaneously with one of...
Search relevance: 80.86 | Views last month: 0 -
Background Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to...
Search relevance: 72.67 | Views last month: 0 -
Background A prospective observational study was done to describe nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus (HIV) infection. ...
Search relevance: 68.40 | Views last month: 0 -
Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces...
Search relevance: 63.64 | Views last month: 0 -
Most techniques that identify antigen-specific T cells are dependent on the response of these cells to the relevant antigen in culture. Soluble multimers of MHC molecules, when occupied with the...
Search relevance: 62.95 | Views last month: 0 -
Background One of the major health problems among HIV seropositive patients is superimposed infection due to the defect of immunity. Furthermore, intestinal parasite infection, which is...
Search relevance: 59.40 | Views last month: 0 -
Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In...
Search relevance: 51.89 | Views last month: 0 -
Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self-reactive T cells. Contact-dependent CD4+ CD25+ 'professional' suppressor cells and other...
Search relevance: 49.91 | Views last month: 1 -
Background HIV-1 is known to play a critical role in the pathogenesis of AIDS-associated Kaposi's sarcoma (KS). However, it remains controversial whether KS cells are target cells for...
Search relevance: 41.72 | Views last month: 1 -
After activation CD4+ helper T cells differentiate into T-helper (Th) 1 or Th2 effector cells. These two subsets are characterized by their distinct cytokine expression pattern and the immune...
Search relevance: 36.16 | Views last month: 1 -
Background The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in infectious, allergic...
Search relevance: 34.97 | Views last month: 1 -
The present disclosure concerns the treatment of a patient with autoimmune disease, including AIDS, by neutralizing, removing or inhibiting different types of interferons, tumor necrosis factor,...
Search relevance: 33.14 | Views last month: 0 -
Background T cells from HIV+ and aged individuals show parallels in terms of suppressed proliferative activity and interleukin-2 (I1-2) production and an increased number of CD8+ CD28- T...
Search relevance: 32.78 | Views last month: 1 -
Background Tuberculosis is responsible for more female deaths around the earth than any other infectious disease. Reports have suggested that responses to tuberculosis may differ between...
Search relevance: 32.19 | Views last month: 1
