Found 33 datasets matching "Mechanism of Action".
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Dataset for Harrill, J.A. et al., 'Signature Analysis of High-Throughput Transcriptomics Screening Data for Mechanistic Inference and Chemical Grouping' published in Toxicological Sciences,...
Search relevance: 57.91 | Views last month: 0 -
A cosmetic or dermatological composition contains by weight (a) a red light-filtering colorant (0.01-5%); and (b) an antiinflammatory agent (0.0001-10%). ACTIVITY : Dermatological;...
Search relevance: 56.68 | Views last month: 1 -
An apparatus and method for selecting and dispensing coverglasses over specimens on slides for the purpose of viewing specimens through a microscope. The selecting device contains a suctioning...
Search relevance: 51.09 | Views last month: 0 -
Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search...
Search relevance: 50.10 | Views last month: 0 -
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke clinical trials. Rapid imaging with...
Search relevance: 50.00 | Views last month: 2 -
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed in the treatment of...
Search relevance: 46.45 | Views last month: 5 -
Aqueous composition (A) for inhalation contains as only active ingredient a tricyclo-oxa-aza-nonane derivative (I), at least one acid and optionally other auxiliaries and/or complexing agents....
Search relevance: 45.50 | Views last month: 0 -
Tumor necrosis factor-α (TNF-α) is a polypeptide cytokine that has been associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology,...
Search relevance: 45.22 | Views last month: 1 -
Background This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown...
Search relevance: 44.04 | Views last month: 0 -
Transformed cells obtained by transferring into normal cells with a gene encoding a protein capable of phosphorylation of p38 protein, or the p38 protein, a variant of the p38 protein, the kinase...
Search relevance: 41.95 | Views last month: 0 -
OCHCO VPE is a repository of DHS-wide HR data including payroll, time & attendance, organization, personal action, etc., it contains current as well as historical information. OCHCO VPE provides...
Search relevance: 41.67 | Views last month: 0 -
Background Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been considered as the main...
Search relevance: 40.02 | Views last month: 0 -
A silicone paint comprises polyorganosiloxane containing at least two unsaturated groups in the molecule; a polyorganohydrogensiloxane containing at least two silicone hydride groups in the...
Search relevance: 37.61 | Views last month: 0 -
Background Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of...
Search relevance: 37.47 | Views last month: 0 -
A motion control system and method that includes a central controller configured to generate first and second demand control signals to be used to define actuation motion of respective first and...
Search relevance: 37.36 | Views last month: 0 -
Pyrimidine derivatives (I) are used as acetylcholinesterase inhibitors. Pyrimidine derivatives of formula (I) are used as acetylcholinesterase inhibitors. R 1, R 3 = H or optionally unsaturated...
Search relevance: 35.67 | Views last month: 0 -
The RENAAL (Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan) study is a multinational, double-blind, randomized, placebo controlled trial which was recently published....
Search relevance: 35.25 | Views last month: 0 -
Background As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold: (1) to fractionate crude extracts from the...
Search relevance: 34.90 | Views last month: 0 -
Background One mechanism that directs the action of the second messengers, cAMP and diacylglycerol, is the compartmentalization of protein kinase A (PKA) and protein kinase C (PKC)....
Search relevance: 34.72 | Views last month: 0 -
The evolution of flow pattern along a single fracture and its effects on heat production is a fundamental problem in the assessments of engineered geothermal systems (EGS). The channelized flow...
Search relevance: 34.72 | Views last month: 0
