Found 18 datasets matching "PBPK model".
-
The data set includes source code that implements a PBPK template model applicable to PFAS. It includes data digitized from Kim et al. (2018), Kim et al. (2019), and Loccisano et al. (2012) used...
Search relevance: 229.31 | Views last month: 12 -
The data set includes source code that implements a PBPK model template that has been extended with features capable of implementing models for volatile organic compounds (VOCs). It also includes...
Search relevance: 220.31 | Views last month: 3 -
The data set includes source code for a "PBPK model template" that can be used to implement physiologically based pharmacokinetic (PBPK) models with various different structural designs and...
Search relevance: 205.45 | Views last month: 1 -
This data set includes source code that implements a PBPK model for naphthalene that allows for inhalation and skin routes of exposure. It also includes data previously published by Kim et al....
Search relevance: 199.62 | Views last month: 1 -
Source Code for the manuscript "Characterizing Variability and Uncertainty for Parameter Subset Selection in PBPK Models" -- This R code generates the results presented in this manuscript; the...
Search relevance: 66.68 | Views last month: 3 -
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for...
Search relevance: 64.07 | Views last month: 0 -
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
Search relevance: 59.44 | Views last month: 1 -
Generic physiologically-based pharmacokinetic (PBPK) models were used to explore how saturable absorption or clearance can influence the shape of the internal to external concentration (IEC)...
Search relevance: 56.64 | Views last month: 1 -
Dataset is a time course description of lindane disappearance in blood plasma after dermal exposure in human volunteers. This dataset is associated with the following publication: Sawyer, M.E.,...
Search relevance: 51.39 | Views last month: 1 -
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC...
Search relevance: 49.71 | Views last month: 2 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 47.20 | Views last month: 1 -
This dataset describes disappearance of chloroform from a vapor uptake chamber with time due to metabolism. The research concentrates on optimization for estimation of metabolic constants using a...
Search relevance: 46.89 | Views last month: 0 -
Estimates of ionization equilibrium constants (i.e., pKa) were analyzed for 8,132 pharmaceuticals and 24,281 other compounds to which humans might be exposed in the environment. Results revealed...
Search relevance: 46.12 | Views last month: 0 -
MCSimMod is a flexible and efficient R package that can be used for implementation and application of physiologically based pharmacokinetic (PBPK) and other ordinary differential equation (ODE) models.
Search relevance: 44.78 | Views last month: 0 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 44.26 | Views last month: 1 -
This dataset contains model code and supporting analysis files necessary to evaluate the impact of variability in human hepatic scaling factors. Variation in scaling factor values impacts...
Search relevance: 42.84 | Views last month: 0 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 38.09 | Views last month: 0
