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Vapor uptake inhalation data for chloroform in F344 rats

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Metadata Last Checked: August 02, 2025 | Last Modified: 2019-07-02
This dataset describes disappearance of chloroform from a vapor uptake chamber with time due to metabolism. The research concentrates on optimization for estimation of metabolic constants using a novel technique. This dataset is associated with the following publication: Evans, M., C. Eklund, D. williams, Y. Sey, and J. Simmons. Global Optimization of the Michaelis-Menten parameters using physiologically-based pharmacokinetic (PBPK) modeling and chloroform vapor uptake data in F344 rats. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 32(3): 97-109, (2020).

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