Found 193 datasets matching "bone".
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Bone loss occurs when the cellular events of bone formation are quantitatively larger than bone formation. This manuscript discusses the measurement of bone loss, occurrence in the population,...
Search relevance: 153.47 | Views last month: 4 -
Osteoporosis is associated with low bone mass and microarchitectural deterioration of bone tissue with clinical manifestation of low trauma fractures. Rheumatoid arthritis (RA) is a risk factor...
Search relevance: 147.68 | Views last month: 2 -
Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of...
Search relevance: 141.47 | Views last month: 0 -
Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of...
Search relevance: 138.30 | Views last month: 1 -
Background Prognosis of chronic osteomyelitis depends heavily on proper identification and treatment of the bone-infecting organism. Current knowledge on selecting the best specimen for...
Search relevance: 135.13 | Views last month: 0 -
The use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to reduce serum cholesterol is well described. However, the recent finding that statins have direct effects on bone...
Search relevance: 133.80 | Views last month: 0 -
This commentary is a concise discussion of the interactions between bone morphogenetic proteins (BMPs) and their binding proteins in bone and cartilage morphogenesis. BMPs are a family of growth...
Search relevance: 129.74 | Views last month: 0 -
Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In bone cells, these inhibitors...
Search relevance: 128.94 | Views last month: 0 -
Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three forms of bone disease have...
Search relevance: 125.65 | Views last month: 0 -
Upper ends of both the metacarpal and metatarsal were cleaned off to solid bone. The lower knuckle was kept intact for the first measurement, then carefully removed to the solid bone for the...
Search relevance: 123.06 | Views last month: 0 -
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering...
Search relevance: 120.85 | Views last month: 0 -
Background Hydroxymethylglutaryl coenzyme A reductase inhibitors increase new bone formation in vitro and in rodents. Results of epidemiologic analyses evaluating the association between...
Search relevance: 120.66 | Views last month: 1 -
Several recent papers have shown that both familial primary pulmonary hypertension (FPPH) and sporadic primary pulmonary hypertension (PPH) may have a common etiology that is associated with the...
Search relevance: 118.32 | Views last month: 0 -
There is often a reciprocal relationship between bone marrow adipocytes and osteoblasts, suggesting that marrow adipose tissue (MAT) antagonizes osteoblast differentiation. MAT is increased in...
Search relevance: 116.05 | Views last month: 0 -
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17...
Search relevance: 114.08 | Views last month: 0 -
Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the treatment of RA....
Search relevance: 113.53 | Views last month: 1 -
Background It has been reported that there is an inverse association between osteoarthritis (OA) and osteoporosis. However, the relationship of bone mass to OA in a Japanese population...
Search relevance: 112.50 | Views last month: 0 -
Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and invade the bone of patients...
Search relevance: 109.17 | Views last month: 1 -
The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors...
Search relevance: 103.42 | Views last month: 0 -
Background Bisphosphonates are indicated in the prevention and treatment of osteoporosis. However, bone mineral density (BMD) continues to decline in up to 15% of bisphosphonate users....
Search relevance: 96.24 | Views last month: 3
