Found 39 datasets matching "candidate gene".
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Background Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is an autosomal dominant eye movement disorder linked to the pericentromere of chromosome 12 (12p11.2 - q12)....
Search relevance: 154.52 | Views last month: 0 -
Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility are actively...
Search relevance: 102.78 | Views last month: 0 -
Background The gene encoding apolipoprotein E (APOE) has been proposed as a candidate gene for vascular complications in Type I diabetes. This study aimed to investigate the influence of...
Search relevance: 60.24 | Views last month: 2 -
Lipid disorders are associated with atherosclerotic vascular disease, and therapy is associated with a substantial reduction in cardiovascular events. Current approaches to the treatment of lipid...
Search relevance: 56.50 | Views last month: 1 -
Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2% of sporadic cases the disease...
Search relevance: 56.28 | Views last month: 0 -
Background Little is known about genetic factors affecting intraocular pressure (IOP) in mice and other mammals. The purpose of this study was to determine the IOPs of genetically...
Search relevance: 53.94 | Views last month: 0 -
Background Celiac disease has a strong genetic association with HLA. However, this association only explains approximately half of the sibling risk for celiac disease. Therefore, other...
Search relevance: 52.72 | Views last month: 3 -
Systemic lupus erythematosus is the prototype multisystem autoimmune disease. A strong genetic component of susceptibility to the disease is well established. Studies of murine models of systemic...
Search relevance: 52.43 | Views last month: 7 -
['Physical inactivity is a risk factor for insulin resistance. We examined the effect of nine days of bed rest on basal and insulin stimulated expression of genes potentially involved in insulin...
Search relevance: 52.41 | Views last month: 0 -
Background Desmuslin is an α-dystrobrevin-interacting protein expressed primarily in heart and skeletal muscle. The desmuslin protein interacts with and is closely related to desmin, a...
Search relevance: 52.38 | Views last month: 2 -
Background: Homeotic genes are key developmental regulators that are highly conserved throughout evolution. Their encoded homeoproteins function as transcription factors to control a...
Search relevance: 52.37 | Views last month: 0 -
We are applying a variety of genetic tools to assess the response of our ocean resources to ocean acidification, including gene expression techniques, identification of candidate genes, and...
Search relevance: 52.23 | Views last month: 0 -
Background The human NOTCH4 gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiological roles. In a British linkage study, NOTCH4 gene polymorphisms...
Search relevance: 51.36 | Views last month: 1 -
Genomics, or the study of genes and their function, is a burgeoning field with many new technologies. In the present review, we explore the application of genomic approaches to the study of...
Search relevance: 50.51 | Views last month: 1 -
Background To support the positional cloning of the mouse mutation wobbler (wr) the corresponding regions on human Chr2p13-14 and mouse Chr11 were analyzed in detail and compared with...
Search relevance: 49.92 | Views last month: 0 -
Background A tetracycline-regulated (conditional) system for RNA interference (RNAi) would have many practical applications. Such a strategy was developed using RNAi of the gene for...
Search relevance: 49.75 | Views last month: 0 -
The filtered VCF file of 10501 SNPs from the 432 individuals in this study. This dataset was used for genome-wide association study (GWAS) and genomic prediction of sugarcane ratooning ability....
Search relevance: 48.37 | Views last month: 0 -
Background Although the genetics of hybrid sterility has been the subject of evolutionary studies for over sixty years, no one has shown the reason(s) why alleles that operate normally...
Search relevance: 48.21 | Views last month: 0 -
This work is part of an experimental trial to develop and assess novel recombinant raccoonpox virus (RCN) rabies vaccines in the mouse model, for potential use in bats. Briefly, our research group...
Search relevance: 48.04 | Views last month: 0 -
Wheat streak mosaic virus (WSMV) can cause significant yield loss in wheat (Triticum aestivum L.) in the Great Plains of North America. A recently identified WSMV resistance gene, Wsm2, was mapped...
Search relevance: 48.00 | Views last month: 3
