• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Some provocative thoughts on damage and repair of DNA

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background It has become increasingly clear that β-cell failure plays a critical role in the pathogenesis of type 2 diabetes. Free-radical mediated β-cell damage has been intensively...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background: Protein fold recognition using sequence profile searches frequently allows prediction of the structure and biochemical mechanisms of proteins with an important biological...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-08-21

This study's objective was to develop an understanding of the biological effects of space radiation on plants with the goal of producing fresh food during long duration space missions to support...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background: Uracil DNA glycosylases (UDGs) are major repair enzymes that protect DNA from mutational damage caused by uracil incorporated as a result of a polymerase error or deamination...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial epithelial cells were...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial epithelial cells were...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Mitotic death is a delayed response of p53 mutant tumours that are resistant to genotoxic damage. Questions surround why this response is so delayed and how its mechanisms serve a survival...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-08-21

These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight conditions. We noted expression...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background The DNA single-strand annealing proteins (SSAPs), such as RecT, Redβ, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. Recently, they...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

In the Rocket Science citizen science project Eruca sativa (salad rocket) seeds stored for six months on board of the International Space Station caused delayed crop establishment. Here we...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

The first global genomic proteomic and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-08-21

The first global genomic, proteomic, and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Background Development of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-04-23

BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR...

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• Organization: National Aeronautics and Space Administration
• Updated: 2025-08-21

Astronauts are exposed to a unique combination of stressors during spaceflight, which leads to alterations in their physiology and potentially increases their susceptibility to infectious...

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