Genetic stabilization by p53 involves growth regulatory and repair pathways
p53 performs a plethora of activities, which are directed towards
the maintenance of the genomic integrity and constitute its
universal role as a tumor suppressor. 1000 to 10000 latent p53
molecules are permanently available in order to monitor DNA
exchange processes in mitotically growing cells. After the
introduction of major DNA injuries the levels of
posttranslationally modified p53 proteins rise, which in turn
transcriptionally signal transient cell cycle arrest or apoptotic
cell death, depending on the extent of damage. Taken together,
p53 inhibits the manifestation of genomic instabilities at
different control levels both during naturally occurring metabolic
processes and in response to genotoxic treatments.
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
]
|
| contactPoint |
{
"fn": "NIH",
"@type": "vcard:Contact",
"hasEmail": "mailto:info@nih.gov"
}
|
| description | p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent p53 molecules are permanently available in order to monitor DNA exchange processes in mitotically growing cells. After the introduction of major DNA injuries the levels of posttranslationally modified p53 proteins rise, which in turn transcriptionally signal transient cell cycle arrest or apoptotic cell death, depending on the extent of damage. Taken together, p53 inhibits the manifestation of genomic instabilities at different control levels both during naturally occurring metabolic processes and in response to genotoxic treatments. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
"description": "Visit the original government dataset for complete information, documentation, and data access.",
"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79672/"
}
]
|
| identifier | https://healthdata.gov/api/views/kvc4-6xuy |
| issued | 2025-07-14 |
| keyword |
[
"dna-repair",
"genomic-stability",
"nih",
"p53-protein",
"tumor-suppression"
]
|
| landingPage | https://healthdata.gov/d/kvc4-6xuy |
| modified | 2025-09-06 |
| programCode |
[
"009:033"
]
|
| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | Genetic stabilization by p53 involves growth regulatory and repair pathways |
