Found 15 datasets matching "p53-protein".
-
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing transcription of...
Search relevance: 265.64 | Views last month: 1 -
Background The p53 protein is activated by genotoxic stress, oncogene expression and during senescence, p53 transcriptionally activates genes involved in growth arrest and apoptosis. p53...
Search relevance: 92.72 | Views last month: 0 -
Background The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible nitric oxide synthase...
Search relevance: 78.88 | Views last month: 0 -
Background The p16INK4A gene product halts cell proliferation by preventing phosphorylation of the Rb protein. The p16INK4a gene is often deleted in human glioblastoma multiforme,...
Search relevance: 63.03 | Views last month: 1 -
Background Loss of activity of tumor suppressor genes is considered a fundamental step in a genetic model of carcinogenesis. Altered expression of the p53 and the Deleted in Colon Cancer...
Search relevance: 58.98 | Views last month: 0 -
Background Acute Intermittent Porphyria is a genetic disorder of heme metabolism, characterized by increased levels of porphyrin precursors, δ-aminolevulinic acid (ALA) and...
Search relevance: 57.65 | Views last month: 0 -
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid arthritis (RA) ...
Search relevance: 55.92 | Views last month: 0 -
Background The tumor suppressor gene PTEN has been found mutated in many types of advanced tumors. When introduced into tumor cells that lack the wild-type allele of the gene, exogenous...
Search relevance: 55.41 | Views last month: 0 -
p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor. 1000 to 10000 latent...
Search relevance: 54.59 | Views last month: 0 -
Cellular senescence is a defining property of euploid cells in culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species exhibit a finite number of...
Search relevance: 52.90 | Views last month: 0 -
Background Development of proximal and distal colorectal cancers involve partly different mechanisms associated with the microsatellite instability (MSI) and the chromosomal instability...
Search relevance: 51.54 | Views last month: 1 -
Background Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20 counteracts...
Search relevance: 46.89 | Views last month: 0 -
Prioritization of chemicals was performed on two Areas of Concerns in the Great Lakes An integrated risk surveillance and monitoring approach was applied Bio-effect prediction methodologies were...
Search relevance: 45.54 | Views last month: 1 -
Radiation affects tissue and cellular integrity at the level of DNA protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and...
Search relevance: 41.05 | Views last month: 0 -
Background: Axillary node status after induction chemotherapy for locally advanced breast cancer has been shown on multivariate analysis to be an independent predictor of relapse....
Search relevance: 33.35 | Views last month: 3
