Cellular senescence:ex vivop53-dependent asymmetric cell kinetics
Cellular senescence is a defining property of euploid cells in
culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species exhibit a finite number of population doublings before undergoing an irreversible arrest of cell replication. Several genes have been implicated as effectors of senescence in culture. These include genetic components of the Rb and p53 growth regulation pathways [3,4,5,6,7,8] and genes encoding components of telomerase [9,10,11]. The p53
and Rb pathways appear to effect senescence proper, being
required for the initial cessation of growth by primary cell
cultures [3,8,12,13,14]. In contrast, the ability of telomerase to extend culture life span is limited to cells that have first escaped senescence [8,12,13,14].
Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[
"009:25"
]
|
| contactPoint |
{
"fn": "NIH",
"@type": "vcard:Contact",
"hasEmail": "mailto:info@nih.gov"
}
|
| description | Cellular senescence is a defining property of euploid cells in culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species exhibit a finite number of population doublings before undergoing an irreversible arrest of cell replication. Several genes have been implicated as effectors of senescence in culture. These include genetic components of the Rb and p53 growth regulation pathways [3,4,5,6,7,8] and genes encoding components of telomerase [9,10,11]. The p53 and Rb pathways appear to effect senescence proper, being required for the initial cessation of growth by primary cell cultures [3,8,12,13,14]. In contrast, the ability of telomerase to extend culture life span is limited to cells that have first escaped senescence [8,12,13,14]. |
| distribution |
[
{
"@type": "dcat:Distribution",
"title": "Official Government Data Source",
"mediaType": "text/html",
"description": "Visit the original government dataset for complete information, documentation, and data access.",
"downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79675/"
}
]
|
| identifier | https://healthdata.gov/api/views/wtbn-ecdj |
| issued | 2025-07-14 |
| keyword |
[
"asymmetric-cell-division",
"cellular-senescence",
"nih",
"p53-protein",
"stem-cell-kinetics"
]
|
| landingPage | https://healthdata.gov/d/wtbn-ecdj |
| modified | 2025-09-29 |
| programCode |
[
"009:033"
]
|
| publisher |
{
"name": "National Institutes of Health",
"@type": "org:Organization"
}
|
| theme |
[
"NIH"
]
|
| title | Cellular senescence:ex vivop53-dependent asymmetric cell kinetics |
