Found 39 datasets matching "gene-polymorphism".
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Background The human NOTCH4 gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiological roles. In a British linkage study, NOTCH4 gene polymorphisms...
Search relevance: 180.40 | Views last month: 1 -
Background Interleukin 6 (IL-6) is thought to play important roles in the development of reactive thrombocytosis caused by inflammation by its stimulatory effect on megakaryocytopoiesis....
Search relevance: 180.29 | Views last month: 2 -
Background The gene encoding apolipoprotein E (APOE) has been proposed as a candidate gene for vascular complications in Type I diabetes. This study aimed to investigate the influence of...
Search relevance: 151.96 | Views last month: 2 -
Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are...
Search relevance: 124.06 | Views last month: 0 -
Background Single-nucleotide polymorphisms (SNPs) are considered to be useful polymorphic markers for genetic studies of polygenic traits. Single-stranded conformational polymorphism...
Search relevance: 113.33 | Views last month: 0 -
Background A close association between Sst I polymorphism in the 3' untranslated region of the apolipoproteinC3 (APOC3) gene and levels of plasma triglycerides (TG) had been reported by...
Search relevance: 101.75 | Views last month: 0 -
The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to...
Search relevance: 75.02 | Views last month: 0 -
Chemical patent from PubChem database. Patent Number: AT-E401425-T1. Title: Novel Chemical Entity. Filing Date: 2011-01-02. Inventors: Smith, John A., Johnson, Mary B.. Abstract: The invention...
Search relevance: 74.68 | Views last month: 1 -
Background The autoimmune thyroid diseases (AITDs), such as Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex interactions between...
Search relevance: 74.37 | Views last month: 0 -
Background Although vitamin D receptor (VDR) polymorphisms have been shown to be associated with abnormal glucose metabolism, the reported polymorphisms are unlikely to have any...
Search relevance: 65.34 | Views last month: 0 -
Background Although all patients undergoing total joint arthroplasty are subjected to similar risk factors that predispose to thromboembolism, only a subset of patients develop this...
Search relevance: 64.43 | Views last month: 0 -
Background Vitamin D has been shown to exert manifold immunomodulatory effects. Type 1 diabetes mellitus (T1DM) is regarded to be immune-mediated and vitamin D prevents the development...
Search relevance: 62.96 | Views last month: 0 -
Background Non-allelic homologous recombination between paralogous repeats is increasingly being recognized as a major mechanism causing both pathogenic microdeletions and duplications,...
Search relevance: 61.10 | Views last month: 1 -
Background The autoimmune thyroid diseases (AITDs), comprising Graves' disease (GD) and Hashimoto's thyroiditis (HT), appear to develop as a result of complex interactions between...
Search relevance: 60.59 | Views last month: 2 -
Background Certain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of...
Search relevance: 58.05 | Views last month: 0 -
Background The human genome contains at least 18 genes for Nudix hydrolase enzymes. Many have similar functions to one another. In order to understand their roles in cell physiology,...
Search relevance: 57.42 | Views last month: 0 -
Background Intronic DNA sequences of the canine arrestin (SAG) gene was screened to identify potential disease causing mutations in dogs with generalized progressive retinal atrophy...
Search relevance: 55.99 | Views last month: 0 -
Osteoporosis (OP) and osteoarthritis (OA), the two most common age-related chronic disorders of articular joints and skeleton, represent a major public health problem in most developed countries....
Search relevance: 55.11 | Views last month: 1 -
Background Women may be at increased risk for venous thromboembolism (VTE) as compared with men. We studied the effects of genetic and biochemical markers of thrombophilia in women, in...
Search relevance: 53.98 | Views last month: 3 -
Background Mutations in the CHK2 gene at chromosome 22q12.1 have been reported in families with Li-Fraumeni syndrome. Chk2 is an effector kinase that is activated in response to DNA...
Search relevance: 53.20 | Views last month: 1
