• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Joint-specific and systemic autoreactivity in the development of inflammatory arthritis

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Hypothalamic–pituitary–adrenal underactivity has been reported in rheumatoid arthritis (RA). This phenomenon has implications with regard to the pathogenesis and treatment of the disease. The...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed in the treatment of...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Chromosomal aberrations were comparatively assessed in nuclei extracted from synovial tissue, primary-culture (P-0) synovial cells, and early-passage synovial fibroblasts (SFB; 98% enrichment;...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory responses to infection. The...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The contribution of osteoclasts to the process of bone loss in inflammatory arthritis has recently been demonstrated. Studies in osteoclast biology have led to the identification of factors...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis (AIA) in the rat knee. In the...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Rheumatoid arthritis represents an excellent model in which to gain insights into the local and systemic effects of joint inflammation on skeletal tissues. Three forms of bone disease have...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

The existence of psoriatic arthritis as a distinct clinical entity remains a topic of debate; some authors propose that it is simply the co-occurrence of psoriasis and inflammatory arthritis....

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Because angiogenesis plays a major role in the perpetuation of inflammatory arthritis, we explored a method for selectively targeting and destroying new synovial blood vessels. Mice with...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Simponi (golimumab) is a prescription medication manufactured by Janssen Biotech, Inc., used as a tumor necrosis factor (TNF) blocker to treat inflammatory conditions like rheumatoid arthritis,...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

There is mounting evidence for a role of the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in inflammatory disease, including arthritis. In the present study, we examined...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator of food intake and energy expenditure, for the...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-09-06

Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages...

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• Organization: U.S. Department of Health & Human Services
• Updated: 2025-03-17

Indomethacin is a prescription nonsteroidal anti-inflammatory drug (NSAID) available as 75 mg extended-release oral capsules. It works by inhibiting cyclooxygenase enzymes to reduce pain,...

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