Found 136 datasets matching "molecule".
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Background The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults, Hh signaling can...
Search relevance: 113.89 | Views last month: 0 -
The Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the spaceflight-altered cytosine methylation in two genetic...
Search relevance: 78.91 | Views last month: 0 -
Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway have also been identified. The...
Search relevance: 74.36 | Views last month: 0 -
Background Increasing evidence suggests that the effect of HLA-E on Natural Killer (NK) cell activity can be affected by the nature of the peptides bound to this non-classical, MHC class...
Search relevance: 66.94 | Views last month: 1 -
During our careers, we have developed new and innovative concepts pertaining to the pathophysiology of osteoarthritis which have assisted in the development of new therapeutic approaches....
Search relevance: 61.43 | Views last month: 0 -
The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various...
Search relevance: 55.69 | Views last month: 0 -
Background Previous work, by us and others, has shown that mammalian galectins-1 have a growth-inhibitory activity for mammalian cells which is apparently independent of their...
Search relevance: 49.74 | Views last month: 0 -
A silicone paint comprises polyorganosiloxane containing at least two unsaturated groups in the molecule; a polyorganohydrogensiloxane containing at least two silicone hydride groups in the...
Search relevance: 41.81 | Views last month: 0 -
PCT No. PCT/US94/10165 Sec. 371 Date Jun. 18, 1996 Sec. 102(e) Date Jun. 18, 1996 PCT Filed Sep. 9, 1994 PCT Pub. No. WO95/07463 PCT Pub. Date Mar. 16, 1995This invention provides a cell...
Search relevance: 37.58 | Views last month: 0 -
TNF-α induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
Background MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-α and is a major determinant of lymphocyte...
Search relevance: 36.61 | Views last month: 0 -
Described are codon optimized sgp130 encoding nucleic acid molecules as well as a method for the highly efficient recombinant production of sgp130 in mammalian cells or bacteria using a nucleic...
Search relevance: 36.10 | Views last month: 0 -
A binding molecule comprising a support structure of at least one cyclic molecular subunit and at least two side chain subunits, where the side chain subunits are polypeptide chains containing...
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There is provided a tolerogenic human peptide, capable of binding to an MHC class I or II molecule without further antigen processing, for use in the treatment and/or prevention of multiple...
Search relevance: 34.24 | Views last month: 0 -
Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell...
Search relevance: 33.76 | Views last month: 0 -
The invention relates to a method for production of alpha,beta-unsaturated amide compounds of general formula (I): whereby (A) a protective group is introduced into a molecule of general formula...
Search relevance: 33.45 | Views last month: 0 -
The invention relates to an isolated DNA molecule comprising the genome of ovine adenovirus OAV287, functionally equivalent DNA molecules or portions thereof. The invention also relates to...
Search relevance: 33.30 | Views last month: 0 -
Background: Tissue damage after ischemia and reperfusion involves leukocyte endothelial interactions mediated by cell adhesion molecules. This study was designed to determine the time...
Search relevance: 32.73 | Views last month: 0 -
Background The use of pretargeting technology for cancer imaging and treatment has made significant progress in the last few years. This approach takes advantage of the fact that biotin...
Search relevance: 31.32 | Views last month: 0 -
Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are...
Search relevance: 31.19 | Views last month: 0 -
Background TEL is a transcriptional repressor containing a SAM domain that forms a helical polymer. In a number of hematologic malignancies, chromosomal translocations lead to aberrant...
Search relevance: 31.15 | Views last month: 1
