Found 91 datasets matching "pathogenesis".
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There is growing evidence that activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years,...
Search relevance: 111.33 | Views last month: 0 -
This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung. Neovascularisation is a fundamental process...
Search relevance: 103.16 | Views last month: 0 -
A recent review article suggested that idiopathic pulmonary fibrosis (IPF) is a disease that is associated more with abnormal wound healing than with inflammation. Data derived from transgenic and...
Search relevance: 100.87 | Views last month: 0 -
The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil...
Search relevance: 91.42 | Views last month: 1 -
Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they...
Search relevance: 90.94 | Views last month: 0 -
Transgenic mice overexpressing IFN-γ in the epidermis develop an inflammatory skin disease resembling cutaneous lupus erythematosus shortly after birth. By 3 months of age, most female transgenics...
Search relevance: 89.49 | Views last month: 0 -
A compilation of previously published results exploring the pathogenesis of avian influenza viruses in wild avian species in North America.
Search relevance: 83.51 | Views last month: 0 -
Changes in influenza viruses that infect pigs have been observed for over two decades. The evolution of these viruses has led to several new strains. For instance, one such strain known as H1N2...
Search relevance: 79.05 | Views last month: 1 -
The extracellular matrix is essential for the integrity of the lung and when disrupted can lead to the architectural changes seen in emphysema. The etiology of emphysema is believed to be due to...
Search relevance: 65.15 | Views last month: 0 -
Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs),...
Search relevance: 56.93 | Views last month: 2 -
Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). One current...
Search relevance: 54.88 | Views last month: 0 -
Background: The H1N1 pandemic (H1N1pdm09) lineage of influenza A viruses (IAV) emerged in North America in 2009 and caused a human influenza pandemic. It spread rapidly due to its efficient...
Search relevance: 50.83 | Views last month: 1 -
Data from influenza A virus (IAV) infected ferrets (Mustela putorius furo) provides invaluable information towards the study of novel and emerging viruses that pose a threat to human health. This...
Search relevance: 47.87 | Views last month: 4 -
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion molecule-1 (VCAM-1), promotion of...
Search relevance: 43.15 | Views last month: 0 -
Data from influenza A virus (IAV) infected ferrets (Mustela putorius furo) provides invaluable information towards the study of novel and emerging viruses that pose a threat to human health. This...
Search relevance: 43.15 | Views last month: 2 -
Treatment groups of ducks were exposed to different virus doses (2, 4, 6 log10 50% egg infectious doses) and by different routes (contact or intrachoanal). The experimental setting was a...
Search relevance: 41.87 | Views last month: 0 -
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important...
Search relevance: 37.90 | Views last month: 0 -
Cytokines play a critical role in regulating lymphoid cell responses to most antigenic stimuli, and it is therefore very likely that these molecules profoundly affect the pathogenesis of...
Search relevance: 37.57 | Views last month: 6 -
The factors that accommodate the transition of different chlamydial species to the persistent state of pathogenesis include marked differences in the strategied deplyed to obtain tryptophan from...
Search relevance: 36.15 | Views last month: 0 -
Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of...
Search relevance: 34.17 | Views last month: 1
