Found 25 datasets matching "pharmacokinetics".
-
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for...
Search relevance: 135.46 | Views last month: 0 -
Background Artesunate is a commonly used antimalarial drug derived from artemisinin. It is rapidly converted to dihydroartemisinin. Little is known on this conversion in the GI tract and...
Search relevance: 93.67 | Views last month: 0 -
Background PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism (FPM) based on the...
Search relevance: 85.45 | Views last month: 1 -
Background It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This assumption may not be...
Search relevance: 85.32 | Views last month: 4 -
This dataset is a collection of .csv's for extracted data from the literature, processing code, and final analysis for manuscript. This dataset is not publicly accessible because: This data is...
Search relevance: 83.39 | Views last month: 1 -
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been designed for specific...
Search relevance: 70.30 | Views last month: 1 -
Dataset is a time course description of lindane disappearance in blood plasma after dermal exposure in human volunteers. This dataset is associated with the following publication: Sawyer, M.E.,...
Search relevance: 41.19 | Views last month: 1 -
httk: High-Throughput Toxicokinetics Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in...
Search relevance: 33.84 | Views last month: 2 -
Generic physiologically-based pharmacokinetic (PBPK) models were used to explore how saturable absorption or clearance can influence the shape of the internal to external concentration (IEC)...
Search relevance: 31.71 | Views last month: 1 -
Here are all of the data files used for this manuscript. Please note that this is all published data. Imran Shah 1.1060+ Chemicals and Chemical controls 2. Chemical descriptors (chm): 2048 Morgan...
Search relevance: 31.48 | Views last month: 2 -
File contains raw data collected on body and organ weights of mice given PFBS and body burden of the chemical after intervals of several hours, as well as expression of liver candidate genes for...
Search relevance: 31.24 | Views last month: 1 -
Pharmacology of the critically ill
Search relevance: 31.10 | Views last month: 0 -
Anatoxin levels in mouse tissues after a single exposure and collected at various timepoints
Search relevance: 30.88 | Views last month: 0 -
Read-across (RAX) is a widely used data gap filling approach and the authors have developed a data-driven tool, called GenRA, to support expert-driven RAX. This work describes a stand-alone Python...
Search relevance: 30.50 | Views last month: 1 -
Acute rat oral toxicity lethality data files, processed prediction files from 2 expert systems. This dataset is associated with the following publication: Nelms, M., A. Karmaus, and G....
Search relevance: 30.50 | Views last month: 0 -
Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") as in Pearce et al. (2017) . Chemical-specific in vitro data have been obtained from relatively...
Search relevance: 30.48 | Views last month: 1 -
Mouse assays. This dataset is associated with the following publication: Diamond, G., K. Bradham, and D. Thomas. Evaluating the Mouse Model for Estimation of Arsenic Bioavailability: Comparison...
Search relevance: 30.23 | Views last month: 0 -
This ScienceHub entry contains a zip file with the pharmacokinetic modeling code used for the linked publication, "Challenges for extrapolation of risk from ingestion to inhalation exposure for...
Search relevance: 29.85 | Views last month: 0 -
This is a new, open, and transparent database of toxicokinetic data supporting EPA decision making. The database has already become the basis of research efforts within EPA to improve HTTK...
Search relevance: 29.77 | Views last month: 30 -
Background This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for the effects of...
Search relevance: 29.12 | Views last month: 2
