Found 15 datasets matching "transgene-expression".
-
Background Electroporation of skeletal muscle after injection of naked DNA was shown by others to increase transgene expression. Information regarding tissue damage caused by...
Search relevance: 99.97 | Views last month: 0 -
Background Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability of...
Search relevance: 79.66 | Views last month: 0 -
Background Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally specialized...
Search relevance: 76.04 | Views last month: 1 -
We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in synoviocyte pathophysiology. Prior...
Search relevance: 72.56 | Views last month: 0 -
Background Rapid, robust and reversible induction of transgene expression would significantly facilitate cancer gene therapy as well as allow the in vivo functional study of newly...
Search relevance: 69.51 | Views last month: 1 -
Background Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing alleles that cause...
Search relevance: 65.66 | Views last month: 0 -
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major problem. The low proliferation...
Search relevance: 60.74 | Views last month: 0 -
Recombinant adenoviruses are straightforward to produce at high titres, have a promiscuous host-range, and, because of their ability to infect nondividing cells, lend themselves to in vivo gene...
Search relevance: 59.56 | Views last month: 0 -
Background Genetic engineering of parthenocarpy confers to horticultural plants the ability to produce fruits under environmental conditions that curtail fruit productivity and quality....
Search relevance: 56.15 | Views last month: 0 -
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-defective adenoviral...
Search relevance: 55.95 | Views last month: 0 -
Comparative gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in the specially designed Mouse...
Search relevance: 53.27 | Views last month: 0 -
Comparitive gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in the specially designed Mouse...
Search relevance: 51.28 | Views last month: 0 -
Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both position effects...
Search relevance: 45.93 | Views last month: 0 -
Background Non-invasive autofluorescent reporters have revolutionized lineage labeling in an array of different organisms. In recent years green fluorescent protein (GFP) from the...
Search relevance: 44.25 | Views last month: 0 -
The data presented are related to the research article entitled "Overexpression of Perilipin1 protects against atheroma progression in apolipoprotein E knockout mice". This Data in Brief paper...
Search relevance: 42.50 | Views last month: 1
