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2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation
The objectives of this work were to: 1) develop an integrated analysis of chemical-mediated effects on steroidogenesis in the HT-H295R assay; and, 2) evaluate whether the HT-H295R assay predicts estrogen and androgen production specifically via comparison with the OECD-validated H295R assay.
This dataset is associated with the following publication:
Haggard, D., A. Karmaus, M. Martin, R. Judson, W. Setzer, and K. Paul-Friedman. (Toxicological Sciences) High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 162(2): 509-534, (2018).
Complete Metadata
| accessLevel | public |
|---|---|
| bureauCode |
[
"020:00"
]
|
| contactPoint |
{
"fn": "Richard Judson",
"hasEmail": "mailto:judson.richard@epa.gov"
}
|
| description | The objectives of this work were to: 1) develop an integrated analysis of chemical-mediated effects on steroidogenesis in the HT-H295R assay; and, 2) evaluate whether the HT-H295R assay predicts estrogen and androgen production specifically via comparison with the OECD-validated H295R assay. This dataset is associated with the following publication: Haggard, D., A. Karmaus, M. Martin, R. Judson, W. Setzer, and K. Paul-Friedman. (Toxicological Sciences) High-throughput H295R steroidogenesis assay: utility as an alternative and a statistical approach to characterize effects on steroidogenesis. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 162(2): 509-534, (2018). |
| distribution |
[
{
"title": "https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/Haggard/2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation/",
"accessURL": "https://gaftp.epa.gov/COMPTOX/NCCT_Publication_Data/Haggard/2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation/"
},
{
"title": "https://github.com/USEPA/CompTox-ToxCast-EDSPsteroidogenesis",
"accessURL": "https://github.com/USEPA/CompTox-ToxCast-EDSPsteroidogenesis"
}
]
|
| identifier | https://doi.org/10.23719/1407003 |
| keyword |
[
"ACToR",
"EDSP21",
"ToxCast",
"steroidogenesi"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2017-09-08 |
| programCode |
[
"020:095"
]
|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.1093/toxsci/kfx274"
]
|
| rights |
null
|
| title | 2017_Prediction_of_H295R_steroidogenesis_Pathway_Perturbation |
