Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific
The dataset is comprised of multiple data-frames. Our focus is on sex and brain region specific responses to ozone in a rat model. The PCR data describes the gene expression from listed brain regions resulting from ozone exposure. Complex enzymes were also assayed due to their sensitivity to oxidative stress using biochemical colorimetric assays. And finally, we collected data for oxidative stress artifacts such as protein carbonyl productions, total antioxidants, and enzyme activity.
This dataset is associated with the following publication:
Valdez, M., D. Freeborn, P. Vulimiri, J. Valdez, U. Kodavanti, and P. Kodavanti. Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific.. International Journal of Molecular Sciences. MDPI, Basel, SWITZERLAND, 24(7): 1, (2023).
Complete Metadata
| accessLevel | public |
|---|---|
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[
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| contactPoint |
{
"fn": "Prasada Kodavanti",
"hasEmail": "mailto:kodavanti.prasada@epa.gov"
}
|
| describedBy | https://pasteur.epa.gov/uploads/10.23719/1528538/documents/datadictionary_MFO3.xlsx |
| describedByType | application/vnd.openxmlformats-officedocument.spreadsheetml.sheet |
| description | The dataset is comprised of multiple data-frames. Our focus is on sex and brain region specific responses to ozone in a rat model. The PCR data describes the gene expression from listed brain regions resulting from ozone exposure. Complex enzymes were also assayed due to their sensitivity to oxidative stress using biochemical colorimetric assays. And finally, we collected data for oxidative stress artifacts such as protein carbonyl productions, total antioxidants, and enzyme activity. This dataset is associated with the following publication: Valdez, M., D. Freeborn, P. Vulimiri, J. Valdez, U. Kodavanti, and P. Kodavanti. Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific.. International Journal of Molecular Sciences. MDPI, Basel, SWITZERLAND, 24(7): 1, (2023). |
| distribution |
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"downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/Gene%20Symbol%20Table.docx"
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"title": "PCRsummary.csv",
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|
| identifier | https://doi.org/10.23719/1528538 |
| keyword |
[
"air pollution",
"brain",
"gender",
"gene expression"
]
|
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2023-02-01 |
| programCode |
[
"020:000"
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|
| publisher |
{
"name": "U.S. EPA Office of Research and Development (ORD)",
"subOrganizationOf": {
"name": "U.S. Environmental Protection Agency",
"subOrganizationOf": {
"name": "U.S. Government"
}
}
}
|
| references |
[
"https://doi.org/10.3390/ijms24076404",
"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094823"
]
|
| rights |
null
|
| title | Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific |
